LIPOPROTEIN AND HYPERTENSION QTL CANDIDATE GENES

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 项目3的目标是在狒狒模型中识别影响与血脂异常、氧化损伤和高血压相关的定量表型的基因。我们目前正在研究内皮脂肪酶变异影响高密度脂蛋白胆固醇(HDLC)变异的分子机制。我们已经确定了影响高密度脂蛋白胆固醇的内皮脂肪酶基因启动子的功能变异。此外，我们已经确定了与这些功能变体中的一个存在差异结合的转录因子，并对这些转录因子在狒狒肝脏中的表达进行了量化，显示了低和高高密度脂蛋白胆固醇之间的差异。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The goal of Project 3 is to identify genes that influence quantitative phenotypes related to dyslipidemia, oxidative damage and hypertension in the baboon model. We are currently studying molecular mechanisms by which variation in endothelial lipase influences variation in high density lipoprotein cholesterol (HDLC). We have identified functional variants in the endothelial lipase gene promoter that influence HDLC. In addition, we have identified transcription factors that differentially bind to one of these functional variants and quantified expression of the transcription factors in baboon liver, demonstrating differences between low and high HDLC baboons.