TULANE COBRE: TRANSGENIC & GENE-TARGETED ANIMAL CORE

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 说明： 转基因和基因靶向动物核心设施为基因工程小鼠和大鼠品系的维护和研究提供了宝贵的资源，这将有助于理解高血压的病理生理以及调节血压和心血管疾病状态的分子机制。这一设施为研究人员提供了独特的资源和标准化方法，以确定转基因和基因靶标小鼠的特征。总体而言，动物核心提供了独特的最先进的标准化方法，以进一步表征新型转基因和基因靶向小鼠模型，以研究血压调节和心血管动态平衡。核心帮助支持初级教员调查人员以及几名高级教员的项目。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. DESCRIPTION: The transgenic and gene-targeted Animal Core Facility serves as a valuable resource for the maintenance and study of genetically engineered mouse and the rat strains that will contribute to the understanding of the pathophysiology of hypertension and the molecular mechanisms regulating blood pressure and cardiovascular disease states. This facility provides investigators access to unique resources and standardized methods to characterize transgenic and gene-targeted mice. Overall, the animal core provides access to unique state-of-the-art standardized methods to further characterize the novel transgenic and gene-targeted mouse models to study the blood pressure regulation and cardiovascular homeostasis. The core helps support project from junior faculty investigators as well as several of the senior faculty.