COBRE for Perinatal Biology

描述(申请人提供)：围产期生物学中心的具体目标是继续我们对围产期生物学领域的科学贡献，并进一步发展妇幼医院的研究事业。这一建议的共同主题是，胎儿或出生后早期的发育调节机制可以重要地为控制细胞功能、器官成熟、健康和以后生活中的疾病的调节机制提供信息。 这一主题将在以下项目中得到重点支持：1)宿主病原体相互作用、发育免疫学和早产儿酵母菌感染的分子发病机制；2)DMA甲基化和染色质重塑作为胎盘中不利的宫内生活和胎儿编程的生物分子“指纹”；3)低氧和低氧调节基因在早期胚胎发生和植入中的作用；4)重述成人心脏损伤的干细胞修复过程中的“胎儿基因程序”；5)先兆子痫的免疫发病机制；6)自然杀伤细胞在成功妊娠结局中的作用。 Cobre的计划目标是继续在促进科学方法的创造力和跨学科合作的跨学科环境中为初级教师提供科学和职业指导。利用我们之前支持时期的资源，我们在基尔古斯研究所建立了一个强大的围产期研究中心，该中心已经成为最先进的研究设施。它容纳了这群初级科学家中的大多数，他们都表现出了独立职业生涯的极大潜力，以及成功的高级调查人员。 这一奖项将使我们能够继续利用我们的计划和我们创造的环境，为所有初级调查人员成为成功的独立调查人员提供所需的各种支持。该奖项将允许他们与各自领域的领先科学家合作，并利用细胞和分子生物学的当代方法来解决围产期和发育生物学中的重要问题。在强有力的调查和探索环境中提供支持性环境，将使我们能够加强/确保他们作为独立调查人员的职业轨迹。 这些区域的临床相关性被它们在发育过程中识别重要机制的高可能性所证明，这些机制在整个生命谱中告知疾病的发病机制。该项目以罗德岛州妇幼医院为基础。它将为初级学院的四个完整项目和两个试点项目提供支持，这些项目将由来自的知名研究人员指导。来自其他中心的一批杰出的研究人员将作为外部科学咨询委员会提供支持和合作。

DESCRIPTION (provided by applicant): The specific aims for the COBRE for Perinatal Biology are to continue our scientific contributions to the field of perinatal biology and to further development of the research enterprise at Women & Infants Hospital. The common theme of this proposal is that mechanisms for regulation of development during the fetal or early postnatal period can inform importantly the regulatory mechanisms governing cell function, organ maturation, health and disease in later life. This theme is highlighted in the projects will support: 1) host pathogen interactions, developmental immunology and the molecular pathogenesis of yeast infections of Candida albicans in the preterm infant; 2) DMA methylation and chromatin remodeling as a biomolecular "fingerprint" in the placenta for adverse intrauterine life and fetal programming; 3) the role of hypoxia and hypoxia-regulated genes in early embryogenesis and implantation; 4) recapitulation of the "fetal gene program" during stem cell repair of cardiac injury in adult life; 5) the immunopathogenesis of preeclampsia; 6) role of natural killer cells in successful pregnancy outcomes. The programmatic aims of this COBRE are to continue to provide scientific and career mentorship to Junior Faculty in an interdisciplinary environment that fosters creativity and transdisciplinary collaboration in scientific approaches. Using resources from our prior period of support we have developed a robust perinatal research center in the Kilguss Research Institute which has become a state-of-the-art research facility. It houses the majority of this group of junior scientists, all of whom have demonstrated excellent potential for independent careers, as well as successful, senior investigators. This award will allow us to continue to leverage our programs and the environment we have created into the kinds of support needed by all junior investigators to become successful independent investigators. The award will allow them to collaborate with leading scientists in their fields and to utilize contemporary approaches in cell and molecular biology to address important issues in perinatal and developmental biology. The combination of a supportive environment within a robust setting of inquiry and exploration will allow us to enhance/ensure their career trajectories as independent investigators. The clinical relevance of these areas is borne out by their high likelihood to identify important mechanisms during development which inform the pathogenesis of disease across the life spectrum. This program is based at the Women & Infants Hospital of Rhode Island. It will provide support for four full projects and 2 pilot projects of Junior Faculty who will me mentored by established investigators from. An outstanding group of investigators from other centers will provide support and collaboration as the External Scientific Advisory Committee.