CEREBRAL AUTOREGULATION OF VERY LOW BIRTH WEIGHT, PREMATURE INFANTS

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 早产极低出生体重（VLBW）婴儿由于其 调节脑血流（CBF）的能力不成熟。两种最常见的脑损伤 影响该患者组的是脑室内出血（IVH）和脑室周围出血（IVH）。 白质软化症（PVL）。IVH和PVL的发病高度依赖于CBF的变化。 例如，在IVH的情况下，血流量的减少可导致未成熟毛细血管的损伤， 血管在germ矩阵。如果将来血流增加，这种损伤可能导致出血。 本研究旨在探讨扩散相关光谱（DCS）是否可用于 测量这个脆弱人群的血流变化由于这些婴儿的脆弱状况， 目前还没有几种方法来评估他们的CBF。这些技术都不能监测 一直在床边。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Preterm very-low-birthweight (VLBW) infants are at significant risk of brain injury due to their immature ability to regulate cerebral blood flow (CBF). Two of the most common brain injuries affecting this patient group are intraventricular hemorrhage (IVH) and periventricular leukomalacia (PVL). The onsets of both IVH and PVL are highly dependent on changes in CBF. For example, in the case of IVH, a decrease in blood flow can cause injury to immature capillary vessels in the germinal matrix. This damage can lead to hemorrhage if flow increases in the future. This study aims to investigate whether diffuse correlation spectroscopy (DCS) could be used to measure blood flow changes in this delicate population. Because of these infants' fragile condition, there exist few methods to evaluate their CBF. None of these techniques are able to monitor continuously at the bedside.