EVALUATION OF CIRCULATING LIPOSOMES

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 已经成功地证明了使用微流体技术生产用于化疗药物递送的微米尺寸的充气脂质球。然而，尚未进行脂质体的体内测试。为了研究药物从多层脂质微球进入血液的治疗效率，我们想应用激光扫描共聚焦显微镜来研究脂质微球的存在，并确定其在小鼠背窗室模型中的循环寿命。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The production of micrometer-sized gas-filled lipospheres using microfluidics technology for chemotherapeutic drug delivery has been successfully demonstrated. However, in vivo testing of the lipospheres has not been carried out. In order to study the therapeutic efficiency of drug delivery from multilayer lipospheres into the blood, we would like to apply laser scanning confocal microscopy to investigate the presence of lipospheres and determine its circulation lifetime in the mouse dorsal window chamber model.