DURABILITY OF THE EFFECTS OF TESTOSTERONE AND GROWTH HORMONE SUPPLEMENTATION

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 目的：确定老年男性停止补充睾酮和生长激素后合成代谢效应和不良事件(AEs)的持久性。设计：双盲随机对照试验(2X3析因设计)，检测睾酮凝胶(5g或10g/d)和重组人生长激素(0、3或5ug/kg/d)16周，3个月后随访。研究对象：社区居住的65-90岁老人108人。测量：睾酮和IGF-1水平，身体成分(DEXA)，1-重复最大力量(1-RM)，爬楼梯能力，生活质量(QOL)和活动问卷，AEs。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Objectives: Determine the durability of anabolic effects and adverse events (AEs) after stopping testosterone and growth hormone supplementation in older men. Design: Double-masked, randomized controlled trial (2X3 factorial design) to test testosterone gel (5g or 10g/daily) and rhGH (0, 3, or 5ug/kg/day) for 16-weeks with follow-up 3-months later. Participants: 108 community-dwelling 65-90 year-old-men. Measurements: Testosterone and IGF-1 levels, body composition (DEXA), 1-repetition maximum (1-RM) strength, stair-climbing power, quality-of-life (QOL) and activity questionnaires, AEs.