NEUROCHEMICAL CORRELATES OF PATHOLOGY IN SPINOCEREBELLAR ATAXIAS

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 脊髓-小脑性共济失调的神经化学病理相关性(与哈里·奥尔博士和布伦特·克拉克博士合作，医学和病理学实验室，贝勒医学院胡达·Y·佐格比，由R21 NS060253和Bob Allison共济失调研究中心，Pi Oz支持)：在这个项目中，我们的目标是通过与同一大脑中的组织学结果进行比较来验证神经变性的MRS标记。为此，我们利用多个携带SCA1突变的小鼠系，包括一个治疗模型，以确定高场MRS是否对早期、症状前的神经化学改变以及治疗逆转这些改变敏感。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Neurochemical Correlates of Pathology in Spinocerebellar Ataxias (in collaboration with Dr.s Harry Orr and Brent Clark, Lab Medicine and Pathology and Huda Y. Zoghbi, Baylor College of Medicine, supported by R21 NS060253 and Bob Allison Ataxia Research Center, PI Oz): In this project our goal is to validate the MRS markers of neurodegeneration by comparison to histology findings in the same brains. For this purpose we utilize multiple mouse lines that carry the SCA1 mutation, including a treatment model, in order to determine if high field MRS is sensitive to early, pre-symptomatic neurochemical alterations, as well as to the reversal of such changes with treatment.