DEVELOPMENT OF CUSTOM FAIMS ELECTRONICS

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 近年来，高场不对称波形离子迁移率谱(FAIMS)作为一种附加的离子分离和选择方法在质谱学中得到越来越广泛的应用。对于希望实施自己的FAIMS设计的实验室来说，FAIMS电极的设计和制造相对简单。然而，产生所需的以几百千赫频率振荡的高幅度非对称电场所需的电子设备的建造并不是微不足道的。在这里，我们介绍一种完全定制的电子设备设置，能够提供所需的波形和电压。该装置相对简单，实施成本也不高。我们还提供了在该系统上获得的数据，演示了FAIMS作为离子陷阱质谱仪的气相离子过滤器接口的使用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. High field asymmetric waveform ion mobility spectrometry (FAIMS) has been used increasingly in recent years as an additional method of ion separation and selection before mass spectrometry. The FAIMS electrodes are relatively simple to design and fabricate for laboratories wishing to implement their own FAIMS designs. However, construction of the electronics apparatus needed to produce the required high magnitude asymmetric electric field oscillating at a frequency of several hundred kilohertz is not trivial. Here we present an entirely custom-built electronics setup capable of supplying the required waveforms and voltages. The apparatus is relatively simple and inexpensive to implement. We also present data acquired on this system demonstrating the use of FAIMS as a gas-phase ion filter interface to an ion trap mass spectrometer.