Exergaming Intervention and Breast Cancer Biomarkers in Black Women

描述（由申请人提供）：肥胖本身是一个重大的公共卫生问题，与绝经后乳腺癌发病率和死亡率增加有关。这项研究计划将评估一种新的方法来改善黑人女性的身体活动，黑人女性通常比大多数其他种族和民族的女性更少运动，更超重和肥胖。在这项研究中，我们将使用一种新的游戏干预策略，并评估其对体重和与肥胖、胰岛素相关途径和炎症相关的生物标志物的影响。我们建议进行为期6个月的双臂随机临床干预试验，使用电子游戏与对照组进行比较。我们将随机抽取100名黑人久坐超重或肥胖女性，将她们分为Wii Fit运动干预组和对照组。本研究的具体目的是：(1)研究在社区环境中进行游戏干预的可行性和可接受性。我们将评估干预方案的总体累积和依从性；(2)探讨Wii Fit运动对久坐超重或肥胖黑人女性心血管健康和体脂率研究终点的干预主要影响。据我们所知，这是第一个调查成人电子游戏干预的研究；(3)研究生物标本采集的可行性

DESCRIPTION (provided by applicant): Obesity itself is a significant public health problem and is associated with increased postmenopausal breast cancer incidence and mortality. This research proposal will assess a novel method to improve physical activity in Black women, who are generally less physically active and more overweight and obese than women of most other racial and ethnic groups. In this study we will use a novel gaming intervention strategy and assess its impact on weight and biomarkers related to obesity, insulin-related pathways and inflammation. We propose a 6 month two-arm randomized clinical intervention trial using video gaming compared to a control group. We will randomize 100 Black sedentary overweight or obese women to either the Wii Fit exercise intervention arm or the control arm. The Specific Aims of the study are: (1) to examine the feasibility and acceptability of an exergaming intervention in a community-based setting. We will assess overall accrual and adherence to the intervention regimen; (2) to explore intervention main effects of exergaming using Wii Fit on study endpoints of cardiovascular fitness and percent body fat in Black women who are sedentary and overweight or obese. To our knowledge, this is the first study investigating a video gaming intervention in adults; (3) to examine the feasibility of collecting biospecimens in a community-based setting; and (4) to explore the impact of the exergaming intervention on biomarkers. PUBLIC HEALTH RELEVANCE: Obesity and physical inactivity are significant public health problems often associated with increased risk of breast cancer. We will use a novel video gaming exercise intervention strategy to reduce weight, increase physical activity, and to favorably impact biomarkers linked to breast cancer. If effective, this intervention is portable an has the potential to impact health disparities related to breast cancer and other obesity-related diseases.