RESOURCE CORE 2: APPLIED PHYSIOLOGY AND TISSUE MECHANISMS

RC-2 心血管去条件性疾病、慢性炎症和内分泌代谢功能障碍是 老年人因慢性致残性疾病所致身体损害的病理生理学 衰老。骨骼减少、体能不佳、炎症、代谢综合征和与残疾相关的急性事件， 如中风和髋部骨折，随着年龄增加而发生，可能会使活动能力变差，增加患上 心血管疾病(CVD)和代谢异常。RC-2的中心假说是运动聚焦 包括有氧和耐力训练在内的康复训练可以改善患者的多个生理系统 年龄较大、行动不便的人会改善功能表现，降低心脏代谢风险， 和预防功能衰退。这一核心侧重于以下具体目标： 1)提供研究支持，指导和培训OAIC学者、初级教员和OAIC研究人员 与运动型相关的应用运动生理学和组织机制研究的绩效 老年慢性致残性疾病患者的功能恢复和功能衰退的预防； 2)促进进行肌肉骨骼和组织机械运动的康复和预防 UM-OAIC试点项目在老龄化和残疾方面的医学研究，RCDC学者和 美国国立卫生研究院和退伍军人事务部资助的外部研究。 我们已经将之前的Pepper Center的两个核心合并为一个更全面的核心 在全身和组织水平上将BASE和临床研究相结合的应用。RC-2领导力 调查人员代表了一个由基础科学家和临床老年医生组成的多学科团队，他们拥有 一起工作了15年。该核心与其他核心和研究工作协同工作 帮助我们从根本上理解运动康复的机制 恢复功能，降低代谢风险，防止残疾人士的功能下降，以及 运动康复增强身体机能和组织代谢的机制。

RC-2 Cardiovascular deconditioning, chronic inflammation, and endocrine-metabolic dysfunction are inherent to the pathophysiology of the physical impairments in older persons hindered by disabling chronic diseases of aging. Sarcopenia, poor fitness, inflammation, metabolic syndrome, and acute events related to disability, such as stroke and hip fracture, occur with advancing age and may worsen mobility and increase risk for cardiovascular disease (CVD) and metabolic abnormalities. The central hypothesis of RC-2 is that exercisefocused rehabilitation including aerobic and resistive training can improve multiple physiological systems in older, mobility limited individuals leading to improved functional performance, reduced cardiometabolic risk, and prevention of functional decline. This core focuses on the following specific aims: 1) To provide study support, mentor and train OAIC scholars, junior faculty and OAIC researchers in the performance of applied exercise physiology and tissue mechanisms research relevant to exercise-based restoration of function and prevention of functional declines in older people with chronic disabling diseases; 2) To facilitate the conduct of musculoskeletal and tissue mechanistic exercise rehabilitation and preventive medical research in aging and disability across the UM-OAIC pilot projects, RCDC Scholars' research and external NIH and VA funded research. We have combined two cores from our prior Pepper Centers into one more comprehensive core in this application that integrates bench and clinical research at the whole body and tissue level. RC-2 leadership and investigators represent a multidisciplinary team of basic scientists with clinical geriatricians who have worked together for 15 years. This core works synergistically with the other cores and research working groups to contribute to our fundamental understanding of the mechanisms by which exercise rehabilitation restores function, reduces metabolic risk and prevents functional decline in disabled individuals, as well as the mechanisms by which exercise rehabilitation enhances physical function and tissue metabolism.