NRSA Hepatology Training Grant

描述（由申请人提供）：肝病学博士后培训计划是UCSF强大的肝脏相关研究工作的一个组成部分。该计划的目的是为学员提供肝脏生物学和疾病的全面背景以及研究技能，以解决新问题并为肝病学的新知识做出贡献。该计划由医学，外科，生物化学和微生物学与免疫学部门的13名教师组成;这些人共同提供基础和临床肝病学方面的平衡专业知识，并具有相互合作的良好记录。一个由5名计划教师组成的小组组成了一个指导委员会，负责筛选申请人，审查培训课程和监测积极受训者的进展。该计划的首要任务是培养被UCSF录取为胃肠病学研究员的医生-科学家。该计划的MD申请人必须有研究成就的先前记录，并致力于肝脏病学的独立调查事业。博士申请人主要来自导师实验室;他们必须表现出类似的学术承诺和对翻译肝脏研究的取向。所有学员都通过核心课程，涵盖肝脏相关的生物学，肝脏相关的研究方法和一般学术技能。然后，他们在个人导师的指导下接受专门的研究指导，选择范围从临床流行病学，健康结果和遗传学到细胞生物学，器官发生，免疫学，代谢和纤维化/致癌。额外的重点课程是强烈建议所有学员;对于那些追求临床研究，在硕士学位课程注册是强制性的。重要的是，培训计划受益于众多的机构资源，包括基础和临床科学的优秀研究生课程以及肝脏中心和临床与转化科学研究所等研究支持单位。项目教师是每个单位的重要人物，因此可以指导学员利用这些资源，最大限度地发挥博士后经验的价值。培训计划的最终目标是提供足够的团体和个人指导，使毕业生能够承担学院级职位，并成功竞争肝脏病学的独立研究资金。 公共卫生相关性：肝病学博士后培训计划旨在为医学博士和博士科学家提供进行与肝脏相关的独立研究的技能。该计划填补了对基础和临床研究人员的需求，他们将指导新的科学知识用于预防，诊断和治疗肝脏相关疾病。培训计划使教师能够提供重点研究指导，每年4名学员。重要的是，它还使受训者能够参加教学课程并获得高级学位。培训计划的最终目标是让毕业生成为独立的研究者，对肝病学领域有意义的贡献者，并希望自己成为导师。期望学员的研究成功将转化为肝病患者的改善结果。

DESCRIPTION (provided by applicant): The Postdoctoral Training Program in Hepatology is an integral part of the robust liver-related research effort at UCSF. The purpose of the Program is to provide trainees a comprehensive background in liver biology and disease as well as the investigational skills to address new questions and contribute to new knowledge in hepatology. The Program is staffed by 13 faculty based within the Departments of Medicine, Surgery, Biochemistry and Microbiology & Immunology; collectively these individuals offer balanced expertise in basic and clinical hepatology and have a strong track record of working collaboratively with each other. A subgroup of 5 Program faculty comprise a Steering Committee charged with screening applicants, reviewing the training curriculum and monitoring the progress of active trainees. The top priority of the Program is to train physician- scientists who are admitted to UCSF as Gastroenterology fellows. MD applicants to the Program must have a prior record of research accomplishment and dedication to an independent investigative career in hepatology. PhD applicants are admitted largely from mentor laboratories; they must display similar academic promise and an orientation toward translational liver research. All trainees are placed through a core curriculum covering liver-related biology, liver-related research methods and general academic skills. They then undergo specialized research instruction under an individual mentor, with choices ranging from clinical epidemiology, health outcomes and genetics to cell biology, organogenesis, immunology, metabolism and fibrosis/carcinogenesis. Additional focused coursework is highly recommended for all trainees; for those pursuing clinical investigation, enrollment in a Master's Degree program is mandatory. Importantly, the Training Program benefits from numerous institutional resources including outstanding graduate programs in basic and clinical sciences as well as research support units such as the Liver Center and the Clinical and Translational Sciences Institute. Program faculty are strong figures in each of these units, and accordingly can guide trainees to utilize these resources to maximize the value of their postdoctoral experience. The ultimate goal of the Training Program is to provide sufficient group and individual mentorship to enable graduates to assume a faculty-level position and compete successfully for independent research funding in hepatology. PUBLIC HEALTH RELEVANCE: Postdoctoral Training Program in Hepatology is designed to provide MD and PhD scientists the skills to conduct independent research relevant to the liver. The Program fills a need for basic and clinical investigators who will direct new scientific knowledge to the prevention, diagnosis and treatment of liver-related ailments. The Training Program enables faculty to provide focused research instruction to 4 trainees per year. Importantly, it also enables trainees to enroll in didactic courses and obtain an advanced degree. The ultimate goal of the Training Program is for graduates to become independent investigators, meaningful contributors to the field of hepatology, and hopefully mentors themselves. The expectation is that the trainees' research successes will translate into improved outcomes for patients suffering from liver diseases.