Parental Occupation and Childhood Cancers

描述（由申请人提供）：癌症是儿童死亡的第二大原因，但尽管进行了广泛的研究，儿童癌症的病因在很大程度上仍然未知。工作场所是环境化学物质和其他物质的重要来源，这些接触可能在不经意间转移到胎儿或家庭。关于父母职业暴露和儿童癌症的研究表明了一些联系，但仍有研究领域未得到充分研究，其中最明显的差距之一是缺乏关于母亲职业暴露的信息。我们建议对1965-2010年在丹麦出生的儿童进行一项大型（N=537,000）巢式病例对照研究，以检查父母职业暴露导致的癌症风险。病例将取自丹麦癌症登记处，对照将随机取自丹麦中央人口登记处。我们将从医学出生登记处获得关于每个孩子围产期历史的额外信息。关于父母职衔的资料可从中央人口登记处获得，关于就业行业的资料将从补充养恤基金获得，该基金是1964年设立的国家养恤金的补充，保留了居住在丹麦的所有就业人员的资料。我们将进一步使用以前为丹麦职业健康研究开发的工作接触矩阵。我们的目的是集中在母亲的职业暴露和疑似致癌物的具体假设，已在文献中观察到。该提案提供了一个令人兴奋的机会来确定特定的癌症职业联系，有可能为工作场所安全监管政策提供信息，并鼓励对治疗和预防策略的研究。

DESCRIPTION (provided by applicant): Cancer is the second leading cause of death among children, but despite extensive research, the etiology of childhood cancers remains largely unknown. The workplace is an important source of environmental chemicals and other agents and these exposures may be inadvertently transferred to the fetus or to the home. Research on parental occupational exposures and childhood cancer has suggested several links, but there remain areas of research that are understudied, with one of the most notable gaps being a lack of information on maternal occupational exposures. We propose a large (N=537,000) nested case-control study of children born in Denmark 1965-2010 to examine risks of cancer from parental occupational exposures. Cases will be taken from the Denmark Cancer Registry and controls will be selected at random from the Denmark Central Population Registry. We will have additional information on each child's peri-natal history from the Medical Births Registry. Information on parental job titles is available from the Central Population Registry and information on industry of employment will be taken from the Supplementary Pension Fund, a supplement to the state pension that was established in 1964 and retains information on all employed persons residing in Denmark. We will further use job-exposure matrices that have been previously developed for studies of occupational health in Denmark. Our aims are to focus on maternal occupational exposures and specific hypotheses of suspected carcinogens that have been observed in the literature. This proposal presents an exciting opportunity to identify specific cancer-occupational links, with the possibility of informing policy on workplace safety regulation and encouraging research on therapeutic and preventive strategies. PUBLIC HEALTH RELEVANCE: Cancer is the second leading cause of death among children, with >10,000 new cases and 2300 cancer deaths expected each year in the US. Unlike with many adult cancers, the etiology of childhood cancers remains poorly understood. This project aims to examine understudied areas of parental exposures to shed light on these complex diseases.