Graduate and Postdoctoral Training in Toxicology

描述(由申请人提供) 这一基础广泛的多学科毒理学和环境健康科学培训计划的主要目的是为在医学院、公共卫生和药学学院以及在环境健康和毒理学方面拥有扎实知识的政府或工业实验室的生物医学研究职业生涯做好准备。22名培训教师代表的研究重点领域包括神经毒性和神经退行性疾病、细胞死亡机制、氧化DNA损伤和修复以及环境评估和流行病学。培训教员的22名成员在研究培训方面取得了成功的记录，目前由总计1000多万美元的联邦拨款资助，其中三分之一来自NIEHS。来自疾病控制中心的几位科学家，包括有毒物质和疾病登记局，也通过客座讲座和合作研究参与了对学生的培训。培训最重要的组成部分是实验室研究，首先是一系列的三次研究轮换，然后是在论文实验室。这一培训还包括毒理学、生物化学、药理学、细胞生物学、分子生物学和生物统计学的核心课程，以及毒理学专业领域的高级课程、研讨会课程和期刊俱乐部。 该项目旨在每年支持约24名学生和30名博士后研究员中的6名学生和3名博士后研究员。完成博士前培训计划的学生将获得广泛的毒理学和环境健康知识，在论文研究领域的深入知识，搜索、批判性阅读和报告生物医学文献的能力，掌握在现代生物医学研究中有用的各种实验室技术，规划和执行研究项目的技能，撰写清晰、准确的科学报告以供发表的能力，以及有效展示研究结果的能力。完成培训计划的博士后研究员将在尖端毒理学研究方面获得丰富的经验，并应提交个人NRSA申请，以获得拨款撰写经验，以帮助过渡到独立的研究职位。 背景 这是埃默里大学提交的这一培训计划的首次竞争性续签。该计划在生物和生物医学科学部(DBBS)的分子药理学计划(MSP)内进行管理定位。该计划的目标是培养训练有素、有竞争力的科学家，致力于与毒理学和环境健康科学相关的富有成效的职业。该项目由加里·米勒博士执导，迪恩·琼斯博士联合执导。在资助的头四年里，该项目招收了第一批博士后学生(共12名)和博士后研究员(共8名)，将参与的教师导师人数从13人扩大到20人，在MSP内开发了毒理学课程，并开始建立挑选和指导学生的程序。

DESCRIPTION (provided by applicant) The primary purpose of this broadly based multidisciplinary toxicology and environmental health sciences training program is to prepare trainees for biomedical research careers in schools of medicine, public health, and pharmacy, and in governmental or industrial laboratories with a sound knowledge in environmental health and toxicology. The areas of research emphasis represented by the 22 training faculty include neurotoxicity and neurodegenerative disease, mechanisms of cell death, oxidative DNA damage and repair, and environmental assessment and epidemiology. The 22 members of the training faculty have an established record of success in research training and are currently funded by a total of over $10,000,000 in federal grants with a third of that being from NIEHS. Several scientists from the Centers for Disease Control, including the Agency for Toxic Substances and Diseases Registry, also participate in the training of students through guest lectures and collaborative research. The most important component of training is laboratory research, first as a series of three research rotations, then in the dissertation laboratory. This training is complemented by core courses in toxicology, biochemistry, pharmacology, cell biology, molecular biology, and biostatistics, and advanced courses in toxicology specialty areas, seminar courses, and journal clubs. The program is designed to support six students and three postdoctoral fellows each year from a total eligible population of about 24 students and 30 postdoctoral fellows. The student who completes the pre-doctoral Training Program will have acquired broad familiarity with toxicology and environmental health, knowledge in depth in the area of dissertation research, the ability to search, read critically and report on the literature of the biomedical sciences, mastery of a variety of laboratory techniques useful in modern biomedical research, skill in planning and executing a research project, ability to write clear, accurate scientific reports for publication, and ability to present effectively the results of research. The postdoctoral fellow who completes the Training Program will have gained extensive experience in cutting edge toxicology research, and should have submitted an individual NRSA application to gain grant writing experience to aid in the transition into an independent research position. BACKGROUND This is the first competitive renewal for this Training Program submitted from Emory University. The program is administratively positioned within the Molecular Pharmacology Program (MSP) within the Division of Biological and Biomedical Sciences (DBBS). The goal of the program is to produce broadly trained, competitive scientists oriented towards productive careers related to the toxicological and environmental health sciences. The program is directed by Dr. Gary Miller and co-directed by Dr. Dean Jones. During the first four years of funding, the program has recruited its first classes of pre-doctoral students (total of 12) and postdoctoral fellows (total of 8), expanded the number of participating faculty mentors from 13 to 20, developed a toxicology curriculum within MSP and began the process of establishing the procedures by which students are selected and mentored.