Improving oesophageal adenocarcinoma outcomes through understanding genomics and treatment toxicity.

食管癌是一种侵袭性癌症，大多数患者存活时间不超过5年。因此，我们需要找到更好的方法来治疗病人。在这项研究中，我们将确定食管癌的DNA突变，这是临床试验的一部分。这些数据使我们能够确定为什么一些肿瘤对治疗反应良好，以及为什么一些患者对治疗有严重的副作用。结果将有助于为未来患者选择治疗方法。

Oesophageal adenocarcinoma is an aggressive cancer, as most patients will not survive for more than 5 years. Therefore we need to find better ways to treat patients. In this study we will identify the DNA mutations in oesophageal cancers that were part of clinical trial. The data allow us to determine why some tumours responded well to therapy, and why some patients had serious side effects to the treatment. The results will help inform on selection of therapy for future patients.