DCP ESP - Support for the ASCUS/LSIL Triage Study for Cervical Cancer (ALTS)

摘要： 该成本中心维护着一个生物库，其中包括参加ASCUS/Lsil宫颈癌分流研究(ALTS)试验的5000名妇女的多个纵向宫颈拭子和血液样本。这些具有良好特征的标本已被用于研究，发表了60多篇论文。它们仍然是评估新的分子标记作为潜在的临床实用分析的宝贵资源。只要样品还在冰柜里，这将是一个正在进行的项目。根据需要储存和检索在临床试验期间收集的血液和宫颈细胞样本。宫颈试管存放在冷藏室中。其他血液和宫颈样本保存在液氮冷冻箱中。血液和组织样本将提供给进行分析的人。 未来，ALTS存储(和检索/处理)资金需求应每年减少约10%-20%。我们将淘汰旧的液体细胞学样本(在冷藏中，但不是冷冻的)，这些样本大多已经用完，但也会随着时间的推移而变质，因此在这一点上没有什么价值。其余的冰冻血清和宫颈样本都很好，仍在使用中。

Abstract: This cost center maintains a biorepository of multiple, longitudinal cervical swabs and blood specimens from 5,000 women who participated in the ASCUS/LSIL Triage Study for Cervical Cancer (ALTS) trial. These well characterized specimens have been utilized in studies resulting in over 60 publications. They continue to be an invaluable resource to evaluate new molecular markers as potential assays for clinical utility. This will be an ongoing project as long as samples remain in the freezers. Storage and retrieval as needed of blood and cervical cell samples that were collected during clinical trial ¿ ALTS. Cervical vials are stored in a cold room. Other blood and cervical samples are stored in liquid nitrogen freezers. Blood and tissue samples will be made available to those conducting the analysis. In the future, the ALTS storage (and retrieval/processing) funding needs should decrease by about 10 - 20 % a year. We will be culling old liquid cytology samples (in cold storage but not frozen) that are mostly used up, but also deteriorate over time and are therefore of little value at the point. The remaining frozen serum and cervical samples are fine and are still being utilized.