Mentoring Research Excellence in Aging and Regenerative Medicine

描述（由申请人提供）：这个COBRE申请的目标是在生物医学衰老研究中发展有前途的初级研究人员的职业生涯，并在该领域建立项目实力。职业发展将利用强大的核心研究导师，他们将提供职业发展建议以及科学发展和实验室管理方面的实用建议。COBRE的五个项目集中在几个互补的主题上，这些主题有助于我们对衰老的理解，从基本遗传和表观遗传的贡献到心血管和神经认知机制。其中三个项目以人类衰老为主题，一个以啮齿动物模型为重点，另一个利用培养细胞。所有的项目都具有高度的翻译相关性。一个由经验丰富的科学家/管理人员组成的内部咨询委员会已经被任命。COBRE领导层由该COBRE的导师和核心高级调查员组成，他们坚定地致力于该计划；这些科学家有着杰出的研究和指导记录。此外，一个杰出的外部顾问委员会将参与指导和评估初级研究人员和COBRE项目本身的进展，这些顾问具有杰出的研究事业和青年科学家的职业发展记录。职业发展将包括一系列的项目会议，参与说教性的拨款写作会议，以及为初级教师和杜兰老龄研究中心的其他成员建立一个高度协作的环境的研讨会。COBRE还为我们的科学家提供生物统计学和基因组学研究核心设施，为他们提供新的实验可能性，并加强实验设计和数据分析。杜兰大学老龄化研究中心为老龄化研究提供了一个优秀的跨学科环境，涉及杜兰大学的八个学院。中心的发展壮大有强大的制度保障。这个COBRE将代表杜兰老龄研究中心的核心，它将有力地促进我们在路易斯安那州建立一个卓越的生物医学老龄研究企业。

DESCRIPTION (provided by applicant): The objective of this COBRE application is to develop the careers of promising junior investigators in biomedical aging research and to build programmatic strength in this area. Career development will utilize a strong core of research mentors who will provide career development advice as well as sound practical advice on scientific development and laboratory management. The five projects in this COBRE focus on several complementary themes that contribute to our understanding of aging, from basic genetic and epigenetic contributions through cardiovascular and neurocognitive mechanisms. Three of the projects feature human aging, one focuses on rodent models, and one utilizes cultured cells. All of the projects have a high translational relevance. An internal advisory committee consisting of seasoned scientist/administrators has been appointed. The COBRE leadership is composed of mentors and core senior investigators for this COBRE, and they are strongly committed to the program; these scientists have outstanding research and mentoring records. In addition, a prominent board of external advisors with outstanding research careers and track records of career development for junior scientists will participate in both the guidance and evaluation of the progress of the junior investigators and of the COBRE program itself. Career development will involve a series of program meetings, exposure to didactic grant-writing sessions, and seminars to develop a highly collaborative environment for both the junior faculty, as well as other members of the Tulane Center for Aging. The COBRE also provides a Biostatistics and Genomics Research Core facility for our scientists to make new experimental possibilities available to them and to enhance experimental design and data analysis. The Tulane Center for Aging provides an outstanding interdisciplinary environment for aging research involving eight of the schools at Tulane University. The Center enjoys strong institutional support for its development and growth. This COBRE will represent the centerpiece of the Tulane Center for Aging, and it will contribute strongly to our building of an exceptional biomedical aging research enterprise in Louisiana.