Liver Disease and HIV

描述（由申请人提供）：肝脏疾病是艾滋病毒感染者发病/死亡的主要原因。肝病的病因包括丙型肝炎病毒（HCV）和乙型肝炎病毒（HBV）感染以及药物引起的肝毒性。HIV对星状细胞激活的直接影响，以及对肝脏细胞因子环境的改变有助于损伤。研究和信息共享仍然分散在专业领域。在不断努力改善沟通、促进研究议程和发展新的富有成效的合作中，我们建议继续举行一系列关于艾滋病毒和肝病的国家/国际会议。拟议的会议将在2012年和2014年举行为期三天的会议，将汇集该领域的主要专家。此外，将鼓励年轻的研究人员和受训人员通过这项赠款支持的奖学金机制参加。会议成果包括提供继续医学教育学分，编写关于该主题的出版手稿，以及提供基于网络的教育网站。与会者将特别注意发展新的研究概念和建立合作协会。

DESCRIPTION (provided by applicant): Liver disease is a major contributor to morbidity/mortality among those with HIV. The etiologies of liver disease include hepatitis C virus (HCV) and hepatitis B virus (HBV) infection as well as drug-induced liver toxicity. Direct effects of HIV on stellate cell activation, and on alteration of the cytokine milieu in the liver contribute to injury. Research and information sharing remain fragmented along specialty lines. In an ongoing effort to improve communication, stimulate the research agenda, and develop new productive collaborations, we propose the continuation of a series of national/international conferences on HIV and liver disease. The proposed conferences will take place over a three day period in 2012, and 2014 which will bring together leading experts in the field. In addition, young investigators and trainees will be encouraged to attend via a scholarship mechanism supported by this grant. Meeting outcomes include provision of continuing medical education credit, development of a published manuscript on the subject, and the availability of a web-based educational site. Particular attention will be paid to development of new research concepts and establishment of collaborative associations by participants.