Psychotherapy Development Research Center

描述（申请人提供）：我们寻求更新心理治疗发展研究中心（PDC），致力于药物滥用心理治疗的开发，评估和社区应用。组织主题是基于心理治疗研究的阶段模型（Rounsaville, Carroll & Onken, 2001）的心理治疗发展和实证检验。PDC的目标是促进创新药物滥用治疗的发展，从仅仅是“好主意”到能够作为经验支持的治疗（EST）广泛使用的治疗方法。在PDC支持的10-14年里，我们成功地开展了最初提出的4个组件研究项目，完成了11个试点项目，并指导了多名新研究员开展了他们的第一个外部支持的行为治疗研究项目。主要发现包括支持PDC开发的干预措施的有效性，包括计算机交付版本的认知行为疗法（CBT4CBT），针对青少年吸烟者的基于学校的应急管理（CM）计划，以及针对可卡因滥用的基于奖励的适应性交付版本的应急管理。我们还为耶鲁大学以外的50个资助项目提供咨询服务，参与了18个多地点的行为和/或药物治疗疗效试验，开发了计算机辅助培训包，以促进更广泛地使用有效的药物滥用治疗，并为许多国家和国际政府组织和团体提供与行为治疗研究相关的问题咨询。在过去的4年里，我们的研究越来越多地集中在检查执行功能受损和冲动作为成瘾的基本组成部分和潜在干预目标的作用上。这项工作需要扩展我们的神经认知评估电池，并在试点和组件研究中纳入创新的fMRI神经成像范式。在更新期间，研究将继续围绕阶段模型与核心设施和3个组成项目组织。核心工作人员将监督一项雄心勃勃的试点研究计划，并为中心项目提供科学监督、管理、标准化心理和神经生物学评估以及技术援助，同时为其他地点的调查人员和临床医生提供咨询和协助。三个后期II期成分临床试验将检验(1)CBT4CBT与认知增强药物的结合，(2)基于奖励的可卡因依赖CM的最佳序列，(3)在基于学校的戒烟计划中结合基于学校的CM与尼古丁替代疗法。

DESCRIPTION (provided by applicant): We seek to renew our psychotherapy development research center (PDC) dedicated to the development, evaluation and community application of psychotherapies for drug abuse. The organizing theme is psychotherapy development and empirical testing based on the Stage Model (Rounsaville, Carroll & Onken, 2001) of psychotherapy research. The PDC's goal is to catalyze the development of innovative drug abuse treatments from the point where they are merely "good ideas" to one where they are capable of widespread use as empirically supported treatments (EST's). In years 10-14 of PDC support we have successfully conducted the 4 originally proposed component research projects, completed 11 pilot projects and guided multiple new investigators to develop their first externally supported research projects on behavioral treatments. Key findings include support for efficacy of PDC developed interventions including a computer delivered version of Cognitive Behavioral Therapy (CBT4CBT), a school based Contingency Management (CM) program for adolescent smokers and an adaptively delivered version of Prize Based CM for cocaine abuse. We have also served as a national resource for psychotherapy research by consulting on 50 funded projects outside Yale, participating in 18 multisite behavioral and/or pharmacotherapy efficacy trials, developing computer-assisted training packages to foster more widespread use of efficacious substance abuse treatments and providing consultation on issues related to behavioral therapies research to numerous national and international government organizations and groups. In the past 4 years our research has been increasingly focused on examining the role of impaired executive functioning and impulsivity as fundamental components of addiction and as potential targets for interventions. This work has entailed expanding our neurocognitive assessment battery and incorporating an innovative fMRI neuroimaging paradigm in pilot and component studies. During the renewal period, research will continue to be organized around the Stage Model with a CORE facility and 3 component projects. Core staff will oversee an ambitious pilot study program and provide scientific oversight, administration, standardized psychological and neurobiological assessments, and technical assistance to center projects along with consultation and assistance to investigators and clinicians at other sites. Three late Stage II component clinical trials will examine (1) combining CBT4CBT with a cognitive-enhancement medication, (2) optimal sequences of Prize Based CM for cocaine dependence and (3) combining school based CM with nicotine replacement therapy in a school based cigarette cessation program. CENTER CHARACTERISTICS