Core C: Biomarkers p426-450

这个核心有两个功能。第一个是通过开展以下工作为其他TCORS调查人员提供服务 为了他们的研究而对生物流体样本的分析。第二是开发新的暴露生物标记物， 可以应用于TCORS调查人员进行的研究，以及推动该领域的发展。我们的 实验室能够测量烟草产品和烟草烟雾中的生物碱和有毒物质。 这些测量是生物标记物开发和解释生物标记物数据所必需的 区分无烟和吸烟烟草的使用。这些测量将包括其他物质 为探讨烟草和烟雾中毒素及毒素前体与接触的关系 用生物标记物确定的。我们预计将制定的经改进的暴露评估措施，以及 它们在TCORS进行的研究中的应用，可以作为未来研究以下风险的模型 新的烟草产品，为其监管提供科学依据。 相关性(请参阅说明)： 生物标记物的开发和验证是FDA法规的高度优先事项。关于烟草的研究 通过生物标志物分析的产品化学可以提供有关哪些物质相关的信息 与人体内的毒素接触有关。吸烟产品中产生有毒物质的前体可能会提供 降低新产品毒性的线索或成为监管的目标。我们期望我们的研究能够 结果改进了确定人类接触烟草和烟草中有毒物质的方法 烟。

This Core serves two functions. The first is to provide a service to other TCORS investigators by carrying out the analysis of biofluid samples for their studies. The second is to develop new biomarkers of exposure that can be applied to the studies carried out by TCORS investigators, as well as to advance the field. Our laboratory is able to measure alkaloids and toxic substances in both tobacco products and in tobacco smoke. These measurements are needed for biomarker development and to interpret the biomarker data for distinguishing smokeless from smoked tobacco use. These measurements will include other substances in order to explore relationships between toxins and toxin precursors in tobacco and smoke with exposure determined using biomarkers. The improved exposure assessment measures that we expect to develop, and their application to studies carried out by the TCORS, could serve as models for future studies of the risks of new tobacco products and provide scientific basis for their regulation. RELEVANCE (See instructions): The development and validation of biomarkers is a high priority issue for FDA regulation. Studies of tobacco product chemistry with biomarker analyses may provide information on which substances are associated with toxin exposure in humans. Precursors in smoking products that generate toxic substances might provide leads for reducing the toxicity of new products or be targets for regulation. We expect that our studies will result in improved methods for determining human exposure to toxic substances in tobacco and tobacco smoke.