Mutant Mouse Regional Resource Center Annual Meeting.

描述(由申请人提供)：突变小鼠区域资源中心(MMRRC)创建于1999年，以满足日益增长的对集中资源的需求，用于存档和向研究社区分发转基因小鼠品系。这些中心是一个多机构、全国分布的资源计划的一部分，有四个信息库，分别位于美国西部(加州大学戴维斯分校)、中央(密苏里大学)和东部(北卡罗来纳大学教堂山分校和杰克逊实验室)，以及一个单一的集中式信息学、协调和服务中心(加州大学戴维斯分校的ICSC)，提供与科学用户社区的单一界面。共同的目标是为研究界提供鼠标模型资源和研究支持服务。此外，这些中心还利用其专业知识研究和实施新的相关技术。随着转基因小鼠产量的大幅增加，这些中心已经扩大到包括作为活克隆、冷冻种质和胚胎干细胞系保存的32,527个突变和转基因小鼠品系的库存，并从全球2000多个机构的3550名研究人员那里获得了约4,080份订单。在国家分布的、多机构的 计划有一个共同的目标，迫切需要高水平的协调沟通。短期战略的日常运作、管理和发展通过电子邮件以及所有中心关键人员和NIH项目工作人员之间的每月电话会议以及针对特定中心需求的小组定期电话会议进行讨论。然而，没有什么可以真正取代定期的面对面会议；因此，这项提案要求为监测、监测和控制中心提供资金，以便在未来五年期间组织和规划年度会议。这样的年度会议对于1)提供足够的时间和面对面的互动来回顾进展并讨论短期和长期规划战略，以确保MMRRC计划继续发展，以满足科学界迅速变化的需求，以及2)提供一个向NIH官员和科学界其他相关成员展示MMRRC计划并邀请他们提供意见的场所，是至关重要的。

DESCRIPTION (provided by applicant): The Mutant Mouse Regional Resource Centers (MMRRC) were created in 1999 to meet the increasing demand for a centralized resource for archiving and distributing genetically modified mouse strains to the research community. The Centers are part of a multi-institutional, nationally distributed resource program with four repositories located strategically in the Western (University of California-Davis), Central (University of Missouri), and Eastern (University of North Carolina-Chapel Hill and The Jackson Laboratory) USA, and a single, centralized Informatics, Coordination and Service Center (ICSC at University of California- Davis) that provides a single interface to the scientific user community. The common goal is to provide mouse model resources and research support services to the research community. In addition, the centers use their expertise to research and implement new related technologies. As the production of genetically engineered mice has increased dramatically, the centers have expanded to include an inventory of over 32,527 mutant and genetically engineered mouse strains maintained as live colonies, cryopreserved germplasm, and embryonic stem (ES) cell lines and have filled ~4,080 orders from ~3550 investigators at over 2000 institutions worldwide. In a nationally distributed, multi-institutional program with a common goal, there is a critical need for high level of coordinated communication. Day-to day operations, management and development of short term strategies are discussed by email as well as in monthly teleconferences between key personnel at all of the Centers and NIH program staff and periodic teleconferences for subgroups addressing specific Center needs. However, there is no real substitute for regular in-person meetings; therefore, this proposal requests funding for the MMRRC to organize and plan annual meetings over the coming five year period. Such annual meetings are critical to 1) provide sufficient time and face-to-face interactions to review progress and discuss short- and long-term planning strategies to ensure that the MMRRC Program continues to evolve to serve the rapidly evolving needs of the scientific community and 2) provides a venue for showcasing the MMRRC program to NIH officers and other relevant members of the scientific community and inviting their input.