Mutant Mouse Regional Resource Center Annual Meeting.

突变小鼠区域资源中心年会。

• 批准号: 8459130
• 负责人: TERRY R MAGNUSON
• 金额: $ 1.8万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-18 至 2017-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8459130
• 关键词: Address; Advisory Committees; Archives; Atlases; Beta Cell; Biological Preservation; Biomedical Research; California; Cellular biology; Collection; Communication; Communities; Country; Defect; Development; Disease susceptibility; ES Cell Line; Electronic Mail; Ensure; Equipment and supply inventories; Funding; Gene Expression; Genes; Genetic; Genetic Models; Genetically Engineered Mouse; Genomics; Goals; Growth; Health; Human; Human Resources; Individual; Informatics; Institution; Life; Link; Medicine; Metric; MicroRNAs; Missouri; Modeling; Monitor; Mouse Strains; Mus; Mutagenesis; Mutant Strains Mice; National Center for Research Resources; Nature; Nervous system structure; Neurosciences; North Carolina; Pathway interactions; Performance; Persons; Pharmacologic Substance; Pigmentation physiologic function; Policies; Principal Investigator; Production; Request for Proposals; Research; Research Infrastructure; Research Personnel; Research Support; Resource Sharing; Resources; Services; Strategic Planning; Subgroup; Technology; Teleconferences; The Jackson Laboratory; Time; U-Series Cooperative Agreements; United States National Institutes of Health; Universities; comparative; cost; human disease; improved; meetings; member; model development; mouse model; mutant; mutant mouse model; operation; organizational structure; programs; promoter; repository; success; symposium; tool

DESCRIPTION (provided by applicant): The Mutant Mouse Regional Resource Centers (MMRRC) were created in 1999 to meet the increasing demand for a centralized resource for archiving and distributing genetically modified mouse strains to the research community. The Centers are part of a multi-institutional, nationally distributed resource program with four repositories located strategically in the Western (University of California-Davis), Central (University of Missouri), and Eastern (University of North Carolina-Chapel Hill and The Jackson Laboratory) USA, and a single, centralized Informatics, Coordination and Service Center (ICSC at University of California- Davis) that provides a single interface to the scientific user community. The common goal is to provide mouse model resources and research support services to the research community. In addition, the centers use their expertise to research and implement new related technologies. As the production of genetically engineered mice has increased dramatically, the centers have expanded to include an inventory of over 32,527 mutant and genetically engineered mouse strains maintained as live colonies, cryopreserved germplasm, and embryonic stem (ES) cell lines and have filled ~4,080 orders from ~3550 investigators at over 2000 institutions worldwide. In a nationally distributed, multi-institutional program with a common goal, there is a critical need for high level of coordinated communication. Day-to day operations, management and development of short term strategies are discussed by email as well as in monthly teleconferences between key personnel at all of the Centers and NIH program staff and periodic teleconferences for subgroups addressing specific Center needs. However, there is no real substitute for regular in-person meetings; therefore, this proposal requests funding for the MMRRC to organize and plan annual meetings over the coming five year period. Such annual meetings are critical to 1) provide sufficient time and face-to-face interactions to review progress and discuss short- and long-term planning strategies to ensure that the MMRRC Program continues to evolve to serve the rapidly evolving needs of the scientific community and 2) provides a venue for showcasing the MMRRC program to NIH officers and other relevant members of the scientific community and inviting their input. PUBLIC HEALTH RELEVANCE (provided by applicant): Mouse genetic models have been developed in large numbers by the biomedical research community as a fundamental tool for examining the genetic pathways underlying human disease conditions and for improving our understanding of human disease susceptibility and the implications for medicine and human health. By serving as a standardized central repository for importing, archiving and distributing mutant mouse strains, the MMRRC protects this valuable resource and provides access to the biomedical research community.

描述（由申请人提供）：突变小鼠区域资源中心（MMRRC）创建于1999年，以满足对集中资源的日益增长的需求，用于将转基因小鼠品系存档和分发给研究界。这些中心是一个多机构、全国性分布的资源项目的一部分，该项目有四个资源库，战略性地位于西部地区。加州大学戴维斯分校（密苏里州大学）和东部（北卡罗来纳大学教堂山分校和杰克逊实验室）美国，和一个单一的，集中的信息学，协调和服务中心（ICSC在加州-戴维斯大学），提供了一个单一的接口，以科学的用户社区。共同的目标是为研究界提供小鼠模型资源和研究支持服务。此外，这些中心还利用其专业知识研究和实施新的相关技术。随着基因工程小鼠的产量急剧增加，这些中心已扩大到包括超过32，527个突变和基因工程小鼠品系的库存，这些品系以活菌落、冷冻保存的种质和胚胎干细胞系的形式保存，并已完成来自全球2000多家机构的约3550名研究人员的约4，080份订单。在一个全国性的、多机构的 计划有一个共同的目标，有一个高层次的协调沟通的迫切需要。通过电子邮件以及所有中心关键人员与NIH项目工作人员之间的每月电话会议以及针对特定中心需求的子组的定期电话会议讨论日常运营、管理和短期战略的制定。然而，没有任何真实的办法可以取代定期的面对面会议;因此，本提案要求为千年发展目标监测和报告资源中心提供资金，以组织和规划未来五年的年度会议。这样的年度会议是至关重要的1）提供足够的时间和面对面的互动，以审查进展情况，并讨论短期和长期的规划战略，以确保MMRRC计划继续发展，以服务于科学界的快速发展的需求和2）提供一个场地展示MMRRC计划NIH官员和其他相关成员的科学界，并邀请他们的投入。 公共卫生相关性（由申请人提供）：生物医学研究界已经大量开发了小鼠遗传模型，作为检查人类疾病基础遗传途径的基本工具，并提高了我们对人类疾病易感性及其对医学和人类健康影响的理解。通过作为一个标准化的中央储存库，用于进口、存档和分发突变小鼠品系，MMRRC保护了这一宝贵的资源，并为生物医学研究界提供了访问途径。