Amplified Attention Training (AAT) for the Treatment of Hemispatial Nelgect

描述（由申请人提供）：当前项目的目标是修改在第一阶段完成的半球忽视的计算机化注意力训练计划（放大注意力训练，AAT）的原型，并进行多地点、随机、对照试验，以确定该人群的有效性。作为一个群体，半脑半球被忽视的患者往往有较差的长期预后，比其他具有相当大小病变的患者群体更有可能需要管理护理。我们最近的研究是第一个证明AAT，针对持续的注意力和警觉性缺陷，可以产生持久的好处。当前项目的总体目标是衡量三个共同的主要结果：注意力、执行功能和功能能力。我们一期试验的证据表明，AAT可以改善半侧忽视常见的注意力和执行功能缺陷。在这个项目完成后，我们将有足够的结果数据提交给FDA，作为半部分忽视的认知增强医疗设备（ICD-9代码781.8）。

DESCRIPTION (provided by applicant): The goal of the current project is to revise a prototype of a computerized attention training program (Amplified Attention Training, AAT) for hemispatial neglect completed in Phase I, and conduct a multi-site, randomized, controlled trial to establish efficacy in this population. As a group, patients with hemispatial neglect tend to have poorer long-term prognosis and are more likely to require managed care than other patient groups with lesions of comparable size. Our recent studies are among the first to demonstrate that AAT, targeting sustained attention & vigilance deficits, can produce lasting benefits. The overall goal of the current project is to measure 3 co-primary outcomes: attention, executive function and functional capacity. Evidence from our Phase I trial shows that AAT can improve attention and executive function deficits common to hemispatial neglect. At the completion of this project we will have outcomes data sufficient for submission to the FDA for clearance as a medical device indicated for cognitive enhancement in hemispatial neglect (ICD-9 Code 781.8).