AN EXERCISE INTERVENTION IN INSULIN-RESISTANT MINORITY ADOLESCENTS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 儿童2型糖尿病发病率的增加与肥胖症患病率的增加是同步的。肥胖通常伴随着胰岛素抵抗和高胰岛素血症，这是2型糖尿病的先兆，并在其发展中起主要作用。这种现象可能与这样一个事实有关，即美国青少年，尤其是女孩，在青春期早期变得不那么活跃，这解释了青少年中主要是青春期和青春期后发病的2型糖尿病。尽管在高危儿童和青少年中，有规律的体育活动被建议用来减轻肥胖和预防2型糖尿病，但运动训练对2型糖尿病风险因素的改善程度最近才在成年人中进行了研究，而在儿科人群中尚未进行研究。本研究的目的是：1)确定运动对胰岛素抵抗的非裔美国人和西班牙裔青少年胰岛素敏感性的影响；2)确定运动对胰岛素抵抗的非裔美国人和西班牙裔青少年纤溶标志物的影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The increased incidence of pediatric type 2 diabetes parallels increased prevalence of obesity. Obesity is commonly accompanied by insulin resistance and hyperinsulinemia, which precedes and plays a major role in the development of type 2 diabetes. This phenomenon may be related with the fact that American adolescents, especially girls, are now becoming less physically active in early puberty, explaining the largely pubertal and post-pubertal onset of type 2 diabetes in adolescents. Although regular physical activity has been suggested to attenuate obesity and prevent type 2 diabetes in high-risk children and adolescents, the magnitude of exercise training-induced improvement in the risk factors for type 2 diabetes has been only recently studied in adults and not studied in pediatric populations. The objectives of this study are: 1) to determine the effects of exercise on insulin sensitivity in insulin-resistant African-American and Hispanic adolescents and 2) to determine the effects of exercise on fibrinolytic markers in insulin-resistant African-American and Hispanic adolescents.