Modeling of Collateral Perfusion in the Ischemic Brain

项目总结/摘要 常见的神经系统疾病构成了越来越可怕的公共卫生负担，需要研究 潜在的机制和充分的努力，以病人为导向的研究（POR）的调查。这个职业生涯中期 应用程序的长期指导计划的目标是培养领先的年轻翻译科学家从不同的 POR中的神经学亚专业，纠正了威胁未来的神经学POR中的指导差距 长期研究项目的目标是增加对中风侧支灌注的理解。 一个创新的指导基础设施，为选定的居民，临床研究员和初级教师提出了与 内容导师在神经亚专业和一个整体POR导师。指导目标包括1） 建立部门指导基础设施，一对一指导，学员研究，职业生涯 开发和网站资源; 2）创建新的神经病学临床和转化研究课程 和科学交流;和3）不断提高教师指导技能。这样做的影响 加州大学洛杉矶分校的辅导计划将通过具体的结果措施进行跟踪，以确保学员的成就 和整个计划的里程碑。这个K24奖项将有助于实现部门的长期目标，以提高 跨神经病学亚专业的POR，建立正式的神经病学POR指导，刺激独立的 研究的受训者和培养一个鼓舞人心的智力环境，以增加未来的神经病学 POR调查员。这种神经学POR培训的综合方法也受益于一项重点研究， 开发中风内容指导侧支灌注模型的策略，该项目提供 在各种POR技术方面提供指导机会。新型神经影像学和血管造影术 方法将用于开发和验证侧支灌注的区域模型， 动脉、组织和静脉中的差异，以预测急性缺血性脑卒中患者的组织命运和神经学结局 中风这一临床相关工作的一个重要课题，在中风护理将提高认识， 灌注，包括脑循环的动脉和静脉段的不同贡献。在 除了提高科学知识和提供指导机会外， 由此产生的产品将是一个软件工具，以加强预测组织命运和神经系统的结果，在急性 脑缺血的各种原因中风。

PROJECT SUMMARY/ABSTRACT Common neurological disorders pose an increasingly formidable public health burden that requires studies of underlying mechanisms and ample effort of patient-oriented research (POR) investigators. This midcareer application's long-term mentoring program goal is to train leading young translational scientists from diverse neurologic subspecialties in POR, redressing the mentoring gap in neurology POR that threatens future progress, and the long-term research project goal is to increase understanding of collateral perfusion in stroke. An innovative mentoring infrastructure for selected residents, clinical fellows and junior faculty is proposed with content mentors in neurologic subspecialties and an overall POR mentor. Mentoring aims include 1) establishing departmental mentoring infrastructure, one-on-one mentoring, trainee research, career development and website resources; 2) creating new courses on neurology clinical and translational research and scientific communications; and 3) continually enhancing faculty mentorship skills. The impact of this mentoring program at UCLA will be tracked with specific outcome measures to ensure achievement of trainee and overall program milestones. This K24 award will help achieve departmental long-term goals to enhance POR across neurologic subspecialties, establish formal neurology POR mentorship, stimulate independent research of trainees and foster an inspiring intellectual environment to increase the number of future neurology POR investigators. This integrated approach to neurology POR training also benefits from a focused research strategy to develop a model of collateral perfusion for content mentoring in stroke, a project that provides mentoring opportunities over a diverse spectrum of POR techniques. Novel neuroimaging and angiography approaches will be used to develop and validate a regional model of collateral perfusion using pressure differentials in arteries, tissue, and veins to predict tissue fate and neurological outcomes in acute ischemic stroke. This clinically relevant work on an important topic in stroke care will enhance understanding of collateral perfusion, including the distinct contributions of arterial and venous segments of the cerebral circulation. In addition to the advancement of scientific knowledge and provision of mentoring opportunities, a tangible resulting product will be a software tool to enhance prediction of tissue fate and neurological outcomes in acute stroke across diverse causes of brain ischemia.