Core E: DIABETES TRANSLATIONAL RESEARCH CORE

多年来，耶鲁大学一直是世界上糖尿病临床和转化研究的主要机构之一。我们的尖端、基础广泛的临床研究计划的传统近年来已扩大到包括闭环泵、功能磁共振、磁共振波谱和正电子发射计算机断层扫描研究、贝塔细胞成像和HD的新免疫疗法等领域。我们的翻译研究组合的扩展是由于糖尿病提供了增强的基础设施 翻译核心(DTRC)。DTRC的主要目标是：1.提供专门的临床和转化性研究基础设施(训练有素的人员、获得设备、实验室资源、研究设施)，以便在糖尿病方面进行复杂的代谢、成像和免疫学研究；2.提供进行各种代谢研究技术(胰岛素-葡萄糖钳，以及 没有磁共振波谱和功能磁共振成像研究、稳定同位素输注、间接量热法、肌肉活组织检查、闭环式胰岛素注射等。)为新的研究人员和研究护理人员提供支持；3.通过生物统计学支持协助赠款和IRB方案的制定，并通过协助招募研究参与者来开展研究。DTRC的第二个目标是协调和便利DRC研究人员访问由CTSA支持的耶鲁临床调查中心(YCCI)提供的扩展的翻译研究资源。在下一个资助期间，DTRC将：1.为以下人员提供研究性护理支持 DTRC调查人员对医院研究单位、磁共振研究中心和PET中心的研究；2.建立一个糖尿病生物统计小组，由Dziura博士(他本身就是一名糖尿病方面的知名调查员)领导，其中将支持硕士级别的生物统计师进行数据分析；3.通过整合耶鲁糖尿病中心扩大对调查人员学科招募的支持 中心登记处是在当前赠款期间开发的，其中包括在线招聘工具、地方社区参与努力以及YCCI糖尿病/新陈代谢研究的研究参与广告活动。DTRC调查人员还将受益于耶鲁信息技术基础设施的增强，包括建立单一的、医疗中心范围的电子病历；实施OnCore；临床研究管理系统；以及建立 临床研究数据仓库。

For many years, Yale has been one ofthe premier institutions in the world for clinical and translational research in diabetes. Our tradition of a cutting edge, broadly based clinical research program has been expanded in recent years to include areas such as, closed loop pumps, functional MRI, MR Spectroscopy and PET studies, beta cell imaging, and new immune-therapeutics forHD. The expansion of our translational research portfolio was made possible by the enhanced infrastructure provided by the Diabetes Translational Core (DTRC). The primary objectives of the DTRC are: 1. To provide specialized clinical and translational research infrastructure (trained personnel, access to equipment, laboratory resources, research facilities) to carry out complex metabolic, imaging, and immunological studies in diabetes; 2. To provide training in the conduct of a wide variety of metabolic research techniques (insulin-glucose clamps, with and without magnetic resonance spectroscopy and functional magnetic resonance imaging studies, stable isotope infusions, indirect calorimetry, muscle biopsies, closed-loop insulin delivery, etc.) for new investigators and research nursing staff; 3.To assist with grant and IRB protocol development via biostatistical support and in carrying out studies by assisting with the recruitment of study participants. A secondary aim of the DTRC is to coordinate and facilitate access of DRC investigators to the expanded translational research resources that are provided by the CTSA-supported Yale Center for Clinical Investigation (YCCI). During the next grant period, the DTRC will: 1. Provide research nursing support for studies of DTRC investigators on the Hospital Research Unit, Magnetic Resonance Research Center and the PET Center; 2. Establish a Diabetes Biostatistics Team, led by Dr. Dziura (an established investigator in diabetes in his own right) that will include support for data analysis by a Master's level Biostatistician; 3. Expand support that is provided to investigators for subject recruitment by integrating the Yale Diabetes Center Registry that was developed during the current grant period with the on-line recruitment instruments, local community engagement efforts and the research participation advertising campaign of YCCI for diabetes/metabolism studies. DTRC Investigators will also benefit from enhancements in informational technology infrastructure at Yale that include establishment of a single, medical center-wide electronic medical record; implementation of OnCore;, a clinical research management system and the establishment of a clinical research data repository.