Tissue Procurement Core

人类生物标本对于转化型癌症研究至关重要。他们提供所需的材料， 直接研究肿瘤形成的机制，以确定与癌症相关的基因和蛋白质 发病机制，以验证生物标志物，可以更好地预测疾病的过程，并开发新的或 为癌症患者提供个性化的医疗治疗。因此，组织采购核心的目标是 (TPC)为癌症中心成员提供集中、综合和具有成本效益的资源， 收集、储存和利用人类生物标本进行转化癌症研究。这一目标是通过 三个相关的目的：1）提供注释的冷冻肿瘤和患者匹配的非恶性肿瘤的一般档案 组织（“肿瘤库”）用于先导性、回顾性相关科学研究; 2）协助研究者 在从参加特定临床试验的受试者中前瞻性采集和储存生物标本时， 3）促进使用人类生物标本及其衍生物进行分子和基因组研究 癌症研究。专门的工作人员和设施用于产生核酸（基因组DNA和RNA）， 用于研究者研究的采集的患者标本的组织学切片。促进基于组织的 激光捕获显微切割和组织微阵列构建等转化研究也 available.积极参与癌症生物医学信息网格（caBlG）计划， 开发和采用caTissue Suite，这是一种最先进的基于网络的软件应用程序，用于跟踪 注释和索取生物样本提高标准化，遵循NCI的办公室， 生物储存库和生物标本研究（OBBR）最佳实践建议，继续改善 核心业务的质量和效率。迄今为止，TPC提供了高质量的生物标本， 为许多资助和出版的研究提供生物技术相关服务，并继续成为国家 生物样本库信息学的领导者。

Human biospecimens are essential for translational cancer research. They provide materials needed to directly investigate the mechanisms of neoplasia, to identify genes and proteins relevant to cancer pathogenesis, to validate biomarkers which can better predict the course of disease, and to develop new or personalized medical therapies for cancer patients. Accordingly, the goal of the Tissue Procurement Core (TPC) is to provide cancer center members with a centralized, integrated, and cost-effective resource to collect, store, and utilize human biospecimens for translational cancer research. This goal is achieved by three related aims: 1) To provide a general archive of annotated frozen tumor and patient-matched nonmalignant tissues ('tumor bank') for pilot, retrospective correlative science studies; 2) To assist investigators in the prospective collection and storage of biospecimens from participants enrolled on specific clinical studies; 3) To facilitate the use of human biospecimens and their derivatives for molecular and genomic cancer research. Dedicated staff and facilities are used to generate nucleic acid (genomic DNA and RNA) and histological sections from collected patient specimens for investigator studies. Technologies to facilitate tissuebased translational research such as laser capture microdissection and tissue microarray construction are also available. Active participation in the Cancer Biomedical Informatics Grid (caBlG¿*) program has resulted in the development and adoption of caTissue Suite, a state-of-the-art web-based, software application for tracking annotating, and requesting biospecimens. Increasing standardization, following the NCI's Office of Biorepositories and Biospecimen Research (OBBR) Best Practices recommendations, continues to improve the quality and efficiency of Core operations. To date, the TPC has provided high-quality biospecimens and biospecimen-related services for numerous funded and published studies, and continues to be a national leader in biospecimen banking informatics.