Investigations of botanicals on food intake, satiety, weight loss, and oxidative

描述(由申请人提供)：到目前为止，我的培训使我对影响饮食行为和体重管理的行为、心理社会和环境因素有了坚实的理解；然而，我对调节饮食行为和体重的生理学和生物学机制的理解仍有待提高。因此，我试图增加我对与年龄相关的代谢状况的生理方面的知识，以及植物提取物在影响生理、饮食行为、体重和氧化应激水平方面的潜在作用。这些知识，再加上我之前的培训，将为我提供一个理想的基础，使我能够建立一条独特而独立的研究路线，研究使用植物药物治疗年龄相关新陈代谢疾病(肥胖症、2型糖尿病)的替代和辅助治疗。我目前的职业目标是1)获得R01补助金，以进一步研究不同剂量的选定植物化合物对食物摄入量、体重和氧化应激水平的潜在影响，以及2)加深我对植物物质对与食物摄入相关的生理过程的影响的理解。我的长期职业目标是成为一名独立的调查员，专注于开发安全有效的替代或辅助干预措施，使用天然化合物治疗肥胖症和其他代谢疾病。拟议的研究路线将探索植物化合物在影响食物摄入量、神经内分泌信号、饱腹感、体重减轻和氧化应激水平方面所起的作用。研究1将采用双盲、安慰剂对照设计，调查两种有前景的植物性药物(藤黄提取的羟基柠檬酸和葡甘聚糖)对食物摄入量、饱腹感和减肥的影响。根据研究1的发现，对食物摄入量有最显著影响的植物将用于一项为期24周的安慰剂控制卡路里限制减肥试验。除了体重，这项试验还将检查所选化合物对以下方面的影响：1)食物摄入量，2)自我报告的饱腹感，3)餐后神经内分泌信号(即CCK、GLP-1、胰岛素和瘦素)，以及4)氧化应激水平(即DNA和RNA氧化)。 公共卫生相关性：植物药是肥胖和胰岛素抵抗患者潜在新辅助疗法的重要来源，并可能通过降低全身氧化应激水平来增强减肥干预的健康益处。

DESCRIPTION (provided by applicant): My training to date has provided me with a solid understanding of the behavioral, psychosocial, and environmental factors that contribute to eating behavior and weight management; however, my understanding of physiology and the biological mechanisms regulating eating behavior and body weight remains to be improved. Therefore, I seek to increase my knowledge of the physiological aspects of age- related metabolic conditions, and the potential role botanical extracts may have in affecting physiology, eating behavior, body weight, and oxidative stress levels. This knowledge, coupled with my previous training, will provide an ideal foundation from which I can build a unique and independent line of research investigating alternative and adjunctive treatments involving botanicals for age-related metabolic conditions (obesity, type 2 diabetes). My immediate career goals are to 1) obtain a R01 grant to further examine the potential effects of different doses of the selected botanical compounds on food intake, body weight, and oxidative stress levels and 2) increase my understanding of the effects that botanicals have on physiological processes related to food intake. My long-term career goal is to become an independent investigator focused on developing safe and effective alternative or adjunctive interventions involving natural compounds for the treatment of obesity and other metabolic conditions. The proposed line of research will explore the role that botanical compounds have in affecting food intake, neuroendocrine signals, satiety, weight loss, and oxidative stress levels. Study 1 will investigate the effects of two promising botanicals (garcinia cambogia derived hydroxycitric acid, and glucomannan) on food intake, satiety, and weight loss using a double-blind, placebo controlled design. Based on the findings from study 1, the botanical with the most significant effects on food intake will be used in a 24-week, placebo controlled calorie restricted weight loss trial. In addition to body weight, this trial will examine the effects of the selected compound on: 1) food intake, 2) self-reported satiety, 3) postprandial neuroendocrine signals (i.e., CCK, GLP-1, insulin, and leptin), and 4) oxidative stress levels (i.e., DNA and RNA oxidation). PUBLIC HEALTH RELEVANCE: Botanicals represent important sources of potential new adjunctive therapies for obese and insulin resistant individuals and may enhance the health benefits of weight loss interventions by reducing systemic oxidative stress levels.