Physiology of Mind-Body Therapies: Meditative Breathing and Autonomic Adaptations

Suzanne M.Bertisch，医学博士，公共卫生硕士，是一名接受临床研究培训的普通内科医生研究员，她拥有 长期以来对心身疗法的兴趣。她的长期目标是发展一项独立的研究 职业生涯研究冥想技巧的生理效应并制定有针对性的循证证据 心血管风险增加人群的心身疗法。她的直接目标是获得 自主心血管生理学和心身临床试验方法学方面的知识和技能。Dr。 Bertisch提出的职业发展计划包括：1)获取实验室测量和数据 心肺生理学分析技能；2)心身医学实践经验 临床试验；3)提高生理学、生物统计学和研究设计方面的知识 教学方法；4)定期与导师和专家协作团队互动。这项建议包括 两个专注于描述身心缓慢呼吸的急性和长期影响的项目 (MBSB)对自主活动的影响。尽管有几个组织做出了努力，但对于急性肺炎仍有许多未知之处 MBSB对大鼠交感神经活动和自主神经张力持续适应的影响 MBSB的重复实践。应聘者计划：1)比较心血管疾病和 长期心身练习者与非心身练习者在急性期对MBSB自主神经的影响 横断面研究；2)评价进行为期12周的随机对照试验的可行性 测量MBSB对肥胖非从业人员自主神经活动和血压的影响 和高血压；并为未来更明确的研究获得初步数据。两个项目都将是 首批使用现代测量和分析技术的公司之一，包括直接测量 交感神经活动。拟议的研究和培训计划的完成将加强Bertisch博士的 能够进行以病人为中心的心身研究，加深对自主神经的理解 心血管生理学，并使她实现了成为一名独立临床医生的职业目标 研究人员研究心身疗法的生理机制和临床应用。 相关性(请参阅说明)： 这一建议的发现将为未来的临床和机制研究提供重要的信息。 心身疗法，特别是在高血压等心血管疾病人群中。更好的 了解心身呼吸练习的临床益处和机制将有助于 开发基于精神和身体的降压靶向疗法。

Suzanne M. Bertisch, MD, MPH,is a general internist fellowship-trained in clinical research, who possesses a long-standing interest in mind-body therapies. Her long-term goal is to develop an independent research career studying the physiological effects of meditative techniques and developing targeted evidence-based mind-body therapies in populations with increased cardiovascular risk. Her immediate goal is to acquire knowledge and skills in autonomic cardiovascular physiology and mind-body clinical trial methodology. Dr. Bertisch's proposed career development plan includes: 1) acquiring laboratory measurement and data analytic skills in cardiopulmonary physiology; 2) gaining experience in the conduct of mind-body medicine clinical trials; 3) improving her knowledge of physiology, biostatistics, and study design through formal didactics; and 4) regular interaction with her mentors and expert collaborative team. This proposal includes two projects that focus on characterizing the acute and long-term effects of mind-body slow breathing (MBSB) upon autonomic activity. Despite efforts by several groups, much remains unknown about the acute effects of MBSB on sympathetic activity and the sustained adaptations in autonomic tone evoked by repetitive practice of MBSB. The candidate plans to: 1) compare the differential cardiovascular and autonomic effects of MBSB among long-term mind-body practitioners and non-practitioners in an acute cross-sectional study; 2) evaluate the feasibility of conducting a 12-week randomized controlled trial measuring the effects of MBSB upon autonomic activity and blood pressure in non-practitioners with obesity and high blood pressure; and obtain preliminary data for future more definitive studies. Both projects will be among the first to use modern measurement and analytic techniques, including a direct measure of sympathetic nerve activity. Completion of the proposed research and training plan will enhance Dr. Bertisch's ability to conduct patient-oriented mind-body research, further her understanding of autonomic cardiovascular physiology, and allow her to achieve her career goal of becoming an independent clinical researcher investigating the physiological mechanisms and clinical applications of mind-body therapies. RELEVANCE (Seeinstructions): Findings from this proposal will provide important information for future clinical and mechanistic studies of mind-body therapies, particularly in cardiovascular disease populations, such as hypertension. A better understanding of the clinical benefits and mechanisms of mind-body-breathing practices will assist the development of targeted mind-body based treatments for lowering blood pressure.