Ureteral Stent Coatings

描述(申请人提供)：这个第一阶段的SBIR项目旨在开发用于输尿管支架的新型可生物降解亲水性涂料。输尿管支架广泛用于维持上尿路引流，并在治疗结石疾病以及其他输尿管梗阻的情况下使用，如损伤、纤维化或恶性肿瘤。然而，与心血管支架不同的是，由于结痂和生物膜的形成，输尿管支架推荐使用3个月或更短时间。超过75%的输尿管支架在这3个月的时间内结皮，使得取出困难，给患者带来痛苦。最好的商业涂层比未涂层的输尿管支架减少了50%的结痂厚度和仅22%的积垢范围。这个项目的重点是新型的生物可降解涂料，这种涂料可以释放旨在最大限度减少结垢的助剂。将对两种不同的制剂进行评估；将在四周内监测释放和体外结皮。

DESCRIPTION (provided by applicant): This Phase I SBIR project is designed to develop new biodegradable hydrophilic coatings for ureteral stents. Ureteral stents are widely used to maintain drainage of the upper urinary tract and instrumental in management of stone disease, as well as in cases of other ureteral obstruction such as injury, fibrosis or malignancies. However, unlike cardiovascular stents, ureteral stents are recommended for use 3 months or less due to encrustation and biofilm formation. Over 75% of ureteral stents are encrusted at this 3 month time period, making removal difficult and causing patients pain. The best commercial coatings reduce encrustation thickness by 50% and extent of encrustion by only 22% over uncoated ureteral stents. This project focuses on novel biodegradable coatings which release agents designed to minimize encrustation. Two different agents will be evaluated; release and in vitro encrustation will be monitored over a four week period.