Southeast Asia Malaria Research Center

东南亚的疟疾控制面临一些严重挑战，需要协调和集中努力。疟疾发病率分布不均和资源有限要求制定适应性强和成本效益高的控制战略。疟疾流行病学、媒介生物学和寄生虫遗传学方面的知识差距阻碍了有效控制措施的制定。寄生虫对青蒿素的新耐药性以及假冒/不合格青蒿素药物的流通威胁到区域和全球疟疾控制运动，需要密切监测并制定适当的对策。为了应对这些挑战，ICEMR项目汇集了美国、泰国、缅甸和中国的优秀机构，这些机构在疟疾研究和培训方面有着国际公认的研究人员合作的历史。在缅甸、中国和泰国选定的战略研究地点，针对该地区最贫困的地区，该联盟将研究对这一被忽视地区重要的紧迫科学问题，这些问题也与全球疟疾控制有关。本课程有三个核心（行政管理、数据管理和分子生物学）和四个科学项目。项目1 “东南亚疟疾流行病学：国家内部和国家间动态”将准确衡量疾病负担的异质性，并提供基本的流行病学信息，以便在流行病学状况各异的多个地点制定和评价综合疟疾控制战略。项目二“东南亚疟疾病媒生物系统和新型病媒控制工具”旨在了解该地区疟疾病媒生物生态，开发创新的疟疾传播监测和控制工具。项目3“恶性疟原虫抗疟药物耐药性”旨在利用高通量全基因组分析工具和来自出现青蒿素耐药性地区的寄生虫种群，阐明青蒿素耐药性的机制。项目4“基于单克隆抗体的青蒿素衍生物检测和定量方法的开发”将开发基于抗体的方法，用于现场条件下青蒿素的定量，以监测药物质量。

Malaria control in Southeast Asia faces a number of serious challenges that require coordinated and focused efforts. The uneven distribution of malaria incidences and limited resources call for the development of adaptable and cost-effective control strategies. Knowledge gaps in malaria epidemiology, vector biology and parasite genetics hinder the development of effective control measures. Emerging resistance of parasites to artemisinins and circulation of counterfeit/substandard artemisinin drugs that threaten regional and global malaria control campaigns demand close monitoring, and development of adequate countermeasures. To address these challenges, this ICEMR program brings together outstanding institutions in the U.S., Thailand, Myanmar and China, where internationally recognized investigators have a history of collaborations in malaria research and training. In strategically selected study sites of Myanmar, China, and Thailand that target the most impoverished areas in this region, this consortium will study urgent scientific questions important to this neglected region that are also pertinent to global malaria control. This program has three cores (administrative, data management, and molecular biology) and four scientific projects. Project 1 "Malaria epidemiology in Southeast Asia: Intra- and inter-country dynamics" will develop an accurate measurement of heterogeneity of the disease burden, and provide essential epidemiological information for developing and evaluating integrated malaria control strategies in multiple sites with varying epidemiological conditions. Project 2 "The malaria vectorial system and new vector control tools in Southeast Asia" aims to understand the ecology of malaria vectors in this region and develop innovative malaria transmission surveillance and control tools. Project 3 "Antimalarial drug resistance in P. falciparum" aims to elucidate the mechanism of artemisinin resistance using a high-throughput, genome-wide analytic tool and parasite populations from areas where artemisinin resistance is emerging. Project 4 "Development of monoclonal antibody-based assays for detection and quantification of artemisinin derivatives" will develop antibody based methods for quantification of artemisinins under field conditions for monitoring drug quality.