PHARMACOLOGY

项目总结(见说明)： 药理学核心机构(PCF)的使命是促进与癌症治疗相关的临床药理学和生物标记物研究。该机构提供全面的实验室服务，支持癌症研究人员进行临床和临床前药物开发研究。PCF现在由一个分析单位和一个生物流体单位组成。这些实验室在血液科/肿瘤科占地3,465平方英尺，还使用位于Duchossois高级医学中心(DCAM)血液学/肿瘤科诊所正对面的IV治疗室(2,662平方英尺)。CORE目前与169项癌症临床研究合作，代表5个UCCCC项目，以及一些组织采购研究。 基金提供的服务包括： 药物和代谢物测定分析方法的发展和实施 在生物体液中 ？临床方案的药代动力学设计和编写辅助； 药代动力学/药效学模型； ？研究静脉切开和静脉插管； ？样品加工； ？收集尿液； ？标本储存、跟踪和存档；以及 心电图仪。

PROJECT SUMMARY (See instructions): The mission of the Pharmacology Core Facility (PCF) is to foster clinical pharmacology and biomarker research regarding cancer therapeutics. The Facility offers comprehensive lab services to support cancer investigators conducting clinical and preclinical drug development studies. The PCF is now comprised of an Analytical Unit and a Biofluids Unit. The labs occupy -3,465 sq ft of space within the Section of Hematology/Oncology, and also utilizes the IV therapy unit (2,662 sq ft) located directly across from the Hematology/Oncology clinic in the Duchossois Center for Advanced Medicine (DCAM). The Core currently works with 169 cancer clinical studies representing 5 UCCCC Programs, and a few tissue procurement studies. Services provided by the PCF include: ¿ development and implementation of analytical assays for measurement of drugs and metabolites in biological fluids ¿ pharmacokinetic design and writing assistance for clinical protocols; ¿ pharmacokinetic/pharmacodynamic modeling; ¿ research phlebotomy and intravenous cannulation; ¿ sample processing; ¿ urine collection; ¿ specimen storage, tracking and archiving; and ¿ electrocardiograms.