Catechol-functionalized Coatings for Medical Devices

描述（由申请人提供）：该项目旨在开发用于医疗器械涂层的新型儿茶酚功能化聚合物，具有更高的润滑性和生物相容性。儿茶酚已被证明是贻贝分泌的附着在水下表面的粘附蛋白的关键成分。儿茶酚具有许多不同的非共价键相互作用，这些相互作用有助于增加儿茶酚功能化分子对有机和无机底物的粘附性。这种能力将用于制造粘附在以前难以涂覆的医疗设备材料（如硅树脂、PEBAX- 72和HDPE）上的涂层，为增强这些材料的设备性能开辟了道路。在第一阶段，儿茶酚通过合成儿茶酚单体并与乙烯基吡咯烷酮共聚而加入，乙烯基吡咯烷酮是一种常用的水凝胶涂层，用于增加涂层的光滑性。虽然儿茶酚以前被附着在其他聚合物上，但它们主要局限于聚乙二醇。该提案的创新之处在于开发儿茶酚功能化聚合物，用于改善医疗设备的润滑涂层。在第二阶段，儿茶酚功能化聚合物将被优化，应用于两种缺乏粘附涂层的商业医疗设备（心血管径向引入器和脑脊液分流器），并扩展到包括血液相容、钝化和非氧化剂依赖共聚物。

DESCRIPTION (provided by applicant): This project is designed to develop novel catechol-functionalized polymers for medical device coatings with increased lubricity and biocompatibility. Catechols have been shown to be key components in the adhesive proteins that mussels secrete to attach to underwater surfaces. The catechol has a number of different non-covalent bond interactions which serve to increase adherence of catechol-functionalized molecules to both organic and inorganic substrates. This ability will be utilized to create coatings that adhere to previously difficult-to-coat medical device materials such as silicone, PEBAX- 72 and HDPE, opening the way to enhanced device properties for these materials. In Phase I, catechols were incorporated by synthesizing a catechol monomer and copolymerizing with vinyl pyrrolidone, a commonly used hydrogel coating for increasing the slipperiness of a coating. While catechols had previously been attached to other polymers, they have been limited primarily to poly(ethylene glycol). The innovation in this proposal lies in the development of catechol-functionalized polymers for improved lubricity coatings for medical devices. In Phase II, the catechol-functionalized polymers will be optimized, applied to two commercial medical devices (cardiovascular radial introducer and a cerebrospinal shunt) that lack adherent coatings, and expanded to include hemocompatible, passivating, and non-oxidant reliant copolymers.