Clinical Evaluation Core

临床评价核心（CEC）的目标是：1.招募、表征和保留人力资源 主题2.所有项目的统一诊断方法和临床评估组合，包括 心理解剖，3。方法开发。4.保持临床工作人员的可靠性。5. 监督住院研究阶段并进行门诊研究阶段6。咨询研究人员。的 CEC识别并招募MDE患者和尸检病例。招募普通志愿者， 提供所用措施的规范值，并在一个 非病态人群CEC使用涵盖主要风险因素的核心临床工具 域的自杀行为，并确保统一的评估领域和措施，在整个 Conte中心的项目。这些评估包括轴I和轴II诊断访谈， 状态和特质相关的危险因素，自杀行为的措施，人口统计学史，生活事件，社会 功能正常家族精神病史在摄入时进行评估，在生物学检查时进行评估。 出院时的程序。CEC与Conte中的其他核心和项目进行了广泛的互动 中心CEC对所有Conte中心项目进行临床评价、数据收集和治疗 包括人类受试者，包括临床项目5、PET项目3、MRI项目4和 统计项目6. CEC与数据管理和统计核心（DMSC）工作人员密切合作， 生成表单、数据管理程序和可靠性统计。CEC与大脑协调 关于受试者招募、临床访谈、匹配对照和监测的成像核心（BIC） 药物流失和主体流动通过脑成像协议。中央选举委员会对 自杀受害者的大脑由死后大脑研究核心（PMC）研究。CEC获得 来自受试者的血液、毛发和唾液，由神经生物学实验室核心（NLC）进行分析。中央选举委员会 还与行政核心接口，以确定和招聘新的工作人员，并维护一个中央数据库 CEC手稿。CEC协调项目#1、2 - 6的诊断共识会议， 保持评分者之间的可靠性。CEC教职员工是一个经验丰富的中心结构，因为大多数有 在过去的10年或更长时间里，

The Clinical Evaluation Core's (CEC) goals are: 1. Recruitment, Characterization and Retention of Human Subjects 2. Uniform Diagnostic Method and Clinical Assessment Battery Across All Projects Including Psychological Autopsies, 3. Methods Development. 4. Maintenance of Reliability among Clinical Staff. 5. Supervise Inpatient Study Phase and Conduct Outpatient Study Phase 6. Consultation to Investigators. The CEC identifies and recruits patients with MDE and post-mortem cases. Normal volunteers are recruited to provide normative values on measures used and to establish psychometric properties of measures in a nonpathological population. The CEC utilizes a core of clinical instruments covering major risk factor domains for suicidal behavior, and ensures uniformity of assessment domains and measures across the projects of the Conte Center. These assessments include Axis I and II diagnostic interviews, measures of state and trait-related risk factors, measures of suicidal behavior, demographic history, life events, social functioning, family psychiatric history. Assessments are performed at intake, at time of biological procedures, at discharge. CEC interacts extensively with other Cores and Projects in the Conte Center. The CEC conducts clinical evaluation, data collection and treatment for all Conte Center projects that include human subjects including the Clinical Project 5, PET Project 3, MRI Project 4 and Statistics Project 6. CEC works closely with the Data Management and Statistics Core (DMSC) staff to generate forms, data management procedures, and reliability statistics. CEC coordinates with the Brain Imaging Core (BIC) regarding subject recruitment, clinical interviewing, matching controls and monitoring drug washouts and subject flow through the brain imaging protocols. The CEC conducts assessments of the suicide victims whose brains are studied by the Postmortem Brain Studies Core (PMC). The CEC obtains blood, hair and saliva from subjects to be analyzed by the Neurobiology Laboratory Core (NLC). The CEC also interfaces with the Administrative Core to identify and recruit new staff and maintain a central database of CEC manuscripts. The CEC coordinates the diagnostic consensus conference for projects # 1 , 2 - 6 and maintains inter-rater reliability. CEC Faculty and staff are an experienced center structure as most have worked as a core for the past 10 years or longer.