A National Short Course in Systems Biology: Tackling Spatial Dynamics in Cells an

描述(由申请者提供)：这项建议旨在建立一个国家系统生物学短期课程，结合数学、统计和计算方法来描述生物系统并了解它们的复杂行为。加州大学欧文分校的复杂生物系统中心(CCBS)非常适合举办这一年度课程，它是美国国立卫生研究院十大系统生物学中心之一。CCBS能够利用来自18个参与的科学系的100多名在职教师的丰富的教师教育和研究专业知识，以及来自荧光动力学实验室(LFD)和基因组和生物信息学研究所等卓越资源机构的贡献，为来自不同科学学科的高级研究生、博士后研究人员、教师和对从事系统生物学研究有新兴趣的行业科学家创建一流的培训课程。课程主题将集中在影响关键细胞过程的空间动力学的系统生物学，包括信号转导网络、细胞分化以及形态发生和图案形成的发育机制。此外，在这些系统中获得的经验将使受训人员能够更普遍地将这些技能应用于具有空间动态特性的其他复杂系统。这一专题领域的研究科学家的征聘和培训目前得不到充分满足，但由于这些过程对许多与人类健康有关的问题至关重要，包括发育异常、与年龄有关的疾病过程、癌症的发生和发展以及可进行系统分析和依赖时空因素的传染病模型，预计需求将会很大。课程形式将结合授课和动手实践实验室，以生物实验和数学/计算建模教程为特色。课程设计分为两个主要部分：一个可选的为期一周的预备入门讲习班(生物学或数学/计算方法)将通过提供基本的跨学科基础教学来解决个别受训人员的教育弱点。第二部分包括为期两周的系统生物学核心课程，通过面向项目的教学和小组互动，提供空间动态研究主题和高级分析生物识别工具(例如，先进的相关光谱学和生物信息数据库的管道查询)的高级介绍。这一独特的方法首先解决特定的受训人员教育缺陷，然后建立强大的跨学科协作工作组，这将促进课程招聘和进入这一领域的研究科学家，他们经常感到感兴趣，但由于之前缺乏正式培训而感到害怕。除了提供密集的现场培训课程外，所有讲座材料(录像)、培训数据集和软件工具都将通过在线分发免费提供，以最大限度地扩大我们的外联工作。

DESCRIPTION (provided by applicant): This proposal aims to establish a National Short Course in Systems Biology that integrates mathematical, statistical and computational approaches to describe biological systems and understand their complex behaviors. The Center for Complex Biological Systems (CCBS) at UC Irvine is ideally suited to host this annual course being one of ten NIH National Centers for Systems Biology. The CCBS is able to leverage substantial faculty educational and research expertise - from a pool of more than 100 active faculty from 18 participating science departments, as well as contributions from preeminent resource facilities such as the Laboratory of Fluorescence Dynamics (LFD) and the Institute for Genomics and Bioinformatics - to create a top-rated training course designed for senior graduate students, postdoctoral researchers, faculty and industry scientists from diverse scientific disciplines who have nascent interests in engaging in Systems Biology research. The course theme will focus on the systems biology of spatial dynamics that impacts key cellular processes including signal transduction networks, cell differentiation, and developmental mechanisms of morphogenesis and patterning. Moreover, experience gained in these systems will enable trainees to apply these skills more generally to other complex systems with spatially dynamic properties. Recruitment and training of research scientists in this thematic area is currently underserved but demand is expected to be significant given the central importance of these processes to many human health related issues, including developmental abnormalities, age-related disease processes, initiation and progression of cancer and infectious disease models that are amenable to systems-oriented analysis and dependent on spatio-temporal factors. The course format will combine didactic lectures with hands-on practical laboratories featuring both biological experimentation and mathematical/computational modeling tutorials. The course design is organized into two principal sections: an optional 1-week Introductory Preparatory Workshop (either in Biology or Mathematical/ Computational Methods) will address individual trainee educational weaknesses by providing essential cross-disciplinary foundational instruction. The second part consists of a 2-week Systems Biology Core Course offering a high-level introduction to spatially dynamic research topics and advanced analytical biometric tools (e.g. advanced correlation spectroscopy and pipeline queries to bioinformatic databases) through project oriented instruction and small group interactions. This unique approach of addressing specific trainee educational deficiencies first, then building strong interdisciplinary collaborative work groups, will enhance course recruitment and entry into this field to research scientists who frequently feel interested but intimidated due to a perceived lack of prior formal training. Beyond providing an intensive on-site training course, all lecture materials (video recorded), training datasets, and software tools will be made freely available through on-line distribution to maximize our outreach efforts.