INTEGRATED SMALL ANIMAL IMAGING RESEARCH RESOURCE

项目概要（见说明）：对癌症的小动物模型进行成像已成为癌症研究的重要组成部分。不断发展的成像技术也提供了不同但互补的成像方法，用于评估潜在的生物学和机制，改善诊断和检测，以及监测癌症治疗的效果。为了充分利用这一快速变化的成像领域，并提供更广泛的成像能力和服务，建立了一个新的综合小动物成像研究资源（iSAlRR），UCCCC和该机构承诺提供大量资源，为小动物的体内成像和组织的离体成像提供广泛的成像模式和技术，提高成本效益和运作效率。这一新的核心设施包括以下四个互补的子核心：1）自2002年以来由CCSG支持的正式的磁共振成像和光谱学设施; 2）正式的光学成像核心设施，这是UCCCC在本周期内的一个发展中核心; 3）新的microPET/SPECT/CT成像设施;以及4）从正式的MRI设施中提取的重组的成像兽医技术支持子核心（IVT），其扩展的使命是为所有动物成像操作提供兽医支持。核心领导层得到了加强，新的科学联合主任和技术主任具有分子成像方面的专业知识。MRI用新的9.4T Bruker系统替换了旧的4.7T磁体，随后获得了额外的梯度线圈、放大器和软件升级，以提高图像分辨率和使用效率。OICF获得了一个新的Xenogen IVIS Spectrum系统，用于动物屏障外，同时将原始Xenogen IVIS 200系统放置在屏障后，以扩大用户访问范围。microPET/SPECT/CT成像服务和能力已通过Gamma Medica三模态临床前成像系统建立。这种新的iSAIRR已经证明了其在推进乳腺癌、肺癌、前列腺癌、卵巢癌、头颈癌、胰腺癌、结直肠癌和脑癌研究中的广泛用途和应用。未来扩展以增强定量多模态成像方法，包括超声和EPRI（电子顺磁共振成像）中的方法，将补充现有的MRIS、光学成像、PET、SPECT和CT服务和能力。

PROJECT SUMMARY (See instructions): Imaging small animal models of cancer has become an essential and integral part of cancer research. Evolving imaging technologies have also made available different but complementary imaging methods for assessing underlying biology and mechanisms, improving diagnosis and detection, and monitoring effects of cancer therapies. To take full advantage of this rapidly changing imaging landscape, and to provide a wider spectrum of imaging capabilities and services, a new Integrated Small Animal Imaging Research Resource (iSAlRR) has been established, with substantial resources committed by the UCCCC and the institution, to offer a broad spectrum of imaging modalities and techniques for in vivo imaging of small animals and ex vivo imaging of tissue/organ specimens with improved cost effectiveness and operational efficiency. This new Core Facility includes the following four complementary subcores: 1) the formal Magnetic Resonance Imaging and Spectroscopy (MRIS) Facility supported by the CCSG since 2002; 2) the formal Optical Imaging Core Facility (OICF), a developing UCCCC core during the current cycle; 3) a new microPET/SPECT/CT imaging facility; and 4) a reorganized Imaging Veterinary Technology support subcore (IVT) extracted from the formal MRIS Facility with an expanded mission of providing veterinary support to all animal imaging operations. The core leadership has been enhanced with new scientific co-directors and technical directors with expertise in molecular imaging. The MRIS replaced the old 4.7T magnet with a new 9.4T Bruker system and subsequently acquired additional gradient coils, amplifier, software upgrades to increase image resolution and usage efficiency. The OICF acquired a new Xenogen IVIS Spectrum system to be used outside the animal barrier, while placing the original Xenogen IVIS 200 system behind the barrier to expand the user access. The microPET/SPECT/CT imaging services and capabilities have been established with a Gamma Medica tri-modality pre-clinical imaging system. This new iSAIRR has already demonstrated its broad usage and applications in advancing research in breast, lung, prostate, ovarian, head and neck, pancreatic, colorectal, and brain cancer. Future expansion to enhance quantitative multi-modality imaging methodologies including those in ultrasound and EPRI (electron paramagnetic resonance imaging) will complement the existing MRIS, optical imaging, PET, SPECT, and CT services and capabilities.