PHARMACOLOGY

项目总结（见说明）： 药理学核心设施（PCF）的使命是促进癌症治疗方面的临床药理学和生物标志物研究。该设施提供全面的实验室服务，以支持癌症研究人员进行临床和临床前药物开发研究。PCF现在由分析股和生物流体股组成。实验室在血液学/肿瘤科占地约3，465平方英尺，还使用了位于Duchossois高级医学中心（DCAM）血液学/肿瘤学诊所正对面的IV治疗单元（2，662平方英尺）。目前，该中心与代表5个UCCCC项目的169项癌症临床研究和一些组织采购研究合作。 基金提供的服务包括： 开发和实施用于测量药物和代谢物的分析测定 生物流体中 药物代谢动力学设计和临床方案的写作协助; 药代动力学/药效学建模; 研究静脉切开术和静脉插管; 样品处理; 尿液收集; 样本存储、跟踪和存档;以及 心电图

PROJECT SUMMARY (See instructions): The mission of the Pharmacology Core Facility (PCF) is to foster clinical pharmacology and biomarker research regarding cancer therapeutics. The Facility offers comprehensive lab services to support cancer investigators conducting clinical and preclinical drug development studies. The PCF is now comprised of an Analytical Unit and a Biofluids Unit. The labs occupy -3,465 sq ft of space within the Section of Hematology/Oncology, and also utilizes the IV therapy unit (2,662 sq ft) located directly across from the Hematology/Oncology clinic in the Duchossois Center for Advanced Medicine (DCAM). The Core currently works with 169 cancer clinical studies representing 5 UCCCC Programs, and a few tissue procurement studies. Services provided by the PCF include: ¿ development and implementation of analytical assays for measurement of drugs and metabolites in biological fluids ¿ pharmacokinetic design and writing assistance for clinical protocols; ¿ pharmacokinetic/pharmacodynamic modeling; ¿ research phlebotomy and intravenous cannulation; ¿ sample processing; ¿ urine collection; ¿ specimen storage, tracking and archiving; and ¿ electrocardiograms.