HUMAN TISSUE RESOURCE CENTER

项目摘要(参见说明)：芝加哥大学综合癌症中心(UCCCC)的总体目标是通过我们的基础、临床、转化和人口研究活动改善癌症的预防、检测和治疗。因此，有效地获取、储存、使用和分析人类生物谱系是至关重要的。此外，这些最先进的生物显微镜设施的维护和扩展对我们癌症项目未来的成功至关重要。 人类组织资源中心(HTRC)的使命是确保人类生物谱系的有效采购、储存、分配、利用和下游分析。该设施在病理科内占有约4,000平方英尺的空间，作为一个综合单位发挥作用。因此，避免了人员、设备和信息系统的重复，并确保了活动的协调。HTRC现在由四个集成的子核组成：生物谱库(BSB)、激光捕获显微切割(LCM)、数字病理学(DP)和组织学服务(HS)。 目前，HTRC为收集临床注释的人体组织以及用于癌症相关研究的血液、血清、血浆和唾液提供服务。此外，该设施还为组织病理学、激光捕获显微解剖、组织微阵列(TMA)制造和定量图像分析提供协作支持和服务。通过这样做，HTRC为癌症研究人员提供了一个集中的基础设施，以优化与涉及人类生物样本的研究相关的效率和成本。

PROJECT SUMMARY (See instructions): The overall goal of the University of Chicago Comprehensive Cancer Center (UCCCC) is to improve the prevention, detection, and treatment of cancer through our basic, clinical, translational, and population research activities. Therefore, the effective procurement, storage, use, and analysis of human biospecimens are of critical importance. Furthermore, the maintenance and expansion of these state-of-the-art biospecimen facilities is vital to the future success of our cancer programs. The mission of the Human Tissue Resource Center (HTRC) is to ensure the effective procurement, storage, distribution, utilization, and downstream analysis of human biospecimens. The Facility occupies ~4,000 sq ft of space within the Pathology Department and functions as an integrated unit. Therefore, duplication of personnel, equipment, and information systems is avoided, and coordination of activities is assured. The HTRC is now comprised of four integrated Subcores: Biospecimen Bank (BSB), Laser Capture Microdissection (LCM), Digital Pathology (DP), and Histology Services (HS). Currently, the HTRC provides services for the collection of clinically-annotated human tissues, as well as blood, serum, plasma, and saliva for cancer-related research. In addition, the Facility provides collaborative support and services for histopathology, laser capture microdissection, tissue microarray (TMA) fabrication and quantitative image analysis. By doing so, the HTRC provides cancer investigators with a centralized infrastructure to optimize the efficiency and costs related to research involving human biospecimens.