Cancer and tobacco control training and research across the lifespan in Kenya

描述（由申请人提供）：癌症负担和烟草消费是肯尼亚发病率和死亡率的主要原因，肯尼亚的研究基础设施有限，严重缺乏应对这些日益严重的慢性非传染性疾病（NCD）对公共卫生的威胁。在内罗毕近15年的长期研究合作的基础上;在埃尔多雷特提供医疗保健机会的20年学术伙伴关系学术模式;利用目前NCI D43培训赠款专门用于艾滋病恶性肿瘤，正在建立关键病理学，肿瘤病毒学和临床试验能力;其他NCI和CDC资助的研究项目;由西弗吉尼亚大学（WVU）的Scot Remick博士和他的肯尼亚高级合作者内罗毕大学（UoN）的Walter Mwanda博士领导的高度互动和经验丰富的研究人员组成的国际团队;肯尼亚医学研究所（KEMRI）的Geoffrey Mutuma博士;内罗毕临终关怀中心的Brigid Sirengo博士、印第安纳州大学（IU）的帕特里克·勒勒博士和他的肯尼亚高级合作者莫伊大学（MU）的Naftali Busakhala博士正在合作开发肯尼亚癌症和烟草控制的可持续研究能力。我们的培训计划将首次连接肯尼亚的5个重要学术医疗和研究中心：内罗毕的UoN健康科学学院和附属肯雅塔国家医院（KNH）; KEMRI;和MU健康科学学院和附属Moi教学和转诊医院（MTRH）在埃尔多雷特。我们的D43培训计划的总体目标是弥合肯尼亚现有的研究能力，使战略和包容性的多学科团队，将提供一个坚实的基础，为发展和实施相关的癌症和烟草控制，将转化为肯尼亚公共卫生政策的循证干预措施。基本目标是加强肯尼亚癌症和烟草控制的基础设施，以便在五年福格蒂奖结束时，高度互动的调查人员和研究人员团队将：（1）登记癌症和其他非传染性疾病实体（例如，（2）制定有效的戒烟和控制策略，以进行社区干预，并进一步制定烟草政策;（3）支持病理学研究项目，以成功完成MMed（病理学）学位课程，培养下一代训练有素的病理学家进行癌症诊断和领导多学科肿瘤委员会;（4）建立癌症临终关怀的研究能力，并制定有效的循证干预措施，特别是针对癌症儿童。常见的培训主题包括：（1）大部分培训将在肯尼亚现场进行，这使我们能够为我们卫生团队的更多成员提供直接培训;（2）解决知识-“人员”和技术-“实验室”能力问题;（3）提供各种短、中、长期的“南南合作”，和电子/网络为基础的培训课程，利用新装修的电子会议室在病理学系在纽约大学的优势;以及（4）为负责任地开展研究、保护人类受试者以及为试点研究奖励机制提供科学/赠款写作方面的培训。

DESCRIPTION (provided by applicant): The burden of cancer and tobacco consumption are major causes of morbidity and mortality in Kenya, a country with limited research infrastructure and significant scarcity to address these ever increasing chronic, non- communicable disease (NCD) threats to public health. Building on a near 15-year long research collaboration in Nairobi; a 20-year long academic partnership Academic Model Providing Access to Healthcare in Eldoret; capitalizing on a current NCI D43 training grant devoted to AIDS malignancy that is building critical pathology, tumor virology and clinical trials capacity; other NCI and CDC-funded research projects; an international team of highly interactive and experienced investigators led by Drs. Scot Remick, West Virginia University (WVU) and his senior Kenyan collaborator Walter Mwanda, University of Nairobi (UoN); Dr. Geoffrey Mutuma at Kenya Medical Research Institute (KEMRI); Dr. Brigid Sirengo at Nairobi Hospice; Dr. Patrick Loehrer at Indiana University (IU) and his senior Kenyan collaborator Dr. Naftali Busakhala, Moi University (MU) are partnering to develop sustainable research capacity for cancer and tobacco control in Kenya across the lifespan. Our training program will link for the first time the 5 essential academic medical and research centers in Kenya: UoN College of Health Sciences and affiliated Kenyatta National Hospital (KNH) in Nairobi; KEMRI; and the MU College of Health Sciences and affiliated Moi Teaching and Referral Hospital (MTRH) in Eldoret. The overall goal of our D43 training program is to bridge existing research capacity in Kenya, enabling strategic and inclusive multidisciplinary teams that will provide a solid foundation for development and implementation of evidence-based interventions relevant to cancer and tobacco control that will translate into Kenyan public health policy. The essential objectives are to strengthen the infrastructure for cancer and tobacco control in Kenya such that by the end of the 5-year Fogarty award highly interactive teams of investigators and research personnel will: (1) register cancer and other NCD entities (e.g., cerebrovascular disease) in population-based registries to inform national health officials and research programs; (2) develop effective tobacco cessation and control strategies for community intervention(s) and further frame tobacco policy; (3) support pathology research projects for successful completion of the MMed(Pathology) degree program to develop the next generation of trained pathologists for cancer diagnosis and lead multidisciplinary tumor boards; and (4) build research capacity for end-of-life cancer care and generate effective evidence-based interventions especially for children with cancer. Common training themes include: (1) the bulk of the training will be on-site in Kenya, which allows us to provide direct training for more members of our health teams; (2) address both intellectual - "people" and technical - "laboratory" capacities; (3) provide a variety of short, medium and long-term, "south-to-south", and electronic/web-based training coursework taking advantage of a newly fit-up electronic conference room in the Department of Pathology at UoN; and (4) provide training for the responsible conduct of research, protections of human subjects, and scientific/grants writing that feeds into a pilot research awards mechanism.