Administrative Core

行政核心将负责监督计划的日常运作，以实现该计划项目拨款的目标。核心将提供行政支助，包括支助赠款和财务管理；安排会议和研讨会；协调POI与UCLA学术和行政机构以及VA大洛杉矶医疗保健系统-西洛杉矶之间的活动。该中心还将为所有研究项目提供生物统计学支持，并管理研究数据和共享数据功能。它将负责管理预算细节，适当归档预算信息，并将提交进度报告并与NCI沟通。行政核心的职责还包括安排、传播信息和组织项目研讨会，包括外部咨询委员会的参与，监督所有关于招募妇女和少数民族的既定政策，以及与NCI其他项目的互动。由Vay Liang W. Go博士和Gang Li博士领导的行政核心将提供生物统计学方面的支持。研究项目包括：项目1研究炎症在饮食诱导胰腺癌发展中的重要性，并探讨前列腺素信号在这一过程中的作用；项目2研究饮食诱导胰腺癌发展中的细胞内信号过程，以及鱼油(1)和二甲双胍(2)在饮食诱导胰腺癌发展中的功效；项目3将研究自噬的重要性。项目4是结缔组织增生在饮食诱导胰腺癌发展中的作用。所有项目都是整合和协同的，并利用两个核心，一个是行政（核心A），一个是动物（核心B）。这些项目还将利用我们的共享核心资源，包括NCCAM资助的加州大学洛杉矶分校胰腺疾病卓越中心、NDDK支持的消化疾病核心中心、NIAAA资助的南加州酒精性肝脏和胰腺疾病中心，以及其他加州大学洛杉矶分校的共享核心资源，以实现该项目的目标，即以饮食促进kras诱导的胰腺癌为目标。

The Administrative Core will be responsible for overseeing the daily functions of the programs in fulfilling the goal of this program project grant. The Core will provide administrative support, including support for grants and financial management; scheduling of meetings and seminars; coordination of activities between this POI and UCLA academic and administrative bodies, and the VA Greater Los Angeles Healthcare System-West Los Angeles. The Core will also provide biostatistical support for all research projects and the management of research data and shared data function of the program. It will have the responsibility of managing details of the budget, appropriately filing budgetary information, and will file progress reports and communicate with NCI. The scheduling, dissemination of information, and organization of the program project Symposium, including the participation of the External Advisory Board, and oversight all of the established policies for recruitment of women and minorities, and interaction with other NCI programs will also be the responsibilities of the Administrative Core. The Administrative Core, under the direction of Dr. Vay Liang W. Go and Dr. Gang Li will provide biostatistical support: The research projects are: Project 1 investigates the importance of inflammation on diet-induced pancreatic cancer development and explores the role of prostaglandin signaling in this process, Project 2 explores in the intracellular signaling processes that are operative in diet- induced pancreatic cancer development and the efficacy of fish oil (1) and metformin (2) in diet-induced pancreatic cancer development, Project 3 will examine the importance of autophagy, and Project 4 is the role of desmoplasia in diet-induced pancreatic cancer development. All projects are integrated and synergistic and utilize two Cores, an Administrative (Core A) and Animal Core (Core B). The projects will also utilize our shared core, including those at NCCAM funded UCLA Center for Excellence in Pancreatic Diseases, NDDK supported Digestive Disease Core Center, NIAAA funded Southern California Center for Alcohol Liver and Pancreatic Disease, other UCLA shared core resources in fulfilling the program project's goal in targeting diet-induced promotion of Kras-induced pancreatic cancer.