Training Program in Biostatistics and Cancer Research

描述(由申请者提供)：项目摘要：本申请是为了继续生物统计学方面的培训计划，重点是癌症研究。该培训计划每年资助6名学生。 生物统计学的实践正在发生变化，特别是在癌症研究领域。在过去的二十年里，对细胞生长和发育的分子、生化和遗传成分的发现改变了我们对是什么使正常细胞癌变然后转移的理解。多学科研究团队是抗击癌症的现代方法的核心，生物统计学家越来越多地成为此类团队的一部分。这种团队合作要求统计学家熟悉分子生物学家、病理学家，当然还有临床肿瘤学家，如果合作调查组要成功的话。因此，有效的生物统计协作需要在统计学、概率、计算方法以及癌症生物学和医学伦理方面进行广泛的培训。统计系、莱斯大学和德克萨斯大学安德森癌症中心定量科学部(UTMDACC)与他们在临床和基础科学方面的合作者共同开发了一项独特的培训计划，将各自的优势结合在一起，培训癌症研究方面的生物统计学家。生物统计学培训计划的目标是培养新一代生物统计学家，他们将在现代癌症研究中与生物医学研究人员并肩工作。我们的计划旨在为学员提供统计和概率方面的严格培训；基础和临床癌症研究的实践经验；以及癌症生物学方面和医学研究伦理方面的培训。 这个项目的学生遵循莱斯大学统计系博士生的标准学习课程，另外还有生物统计学、生物学和伦理学的课程，以及在这两个机构举行的特别研讨会和工作坊。凭借在贝叶斯方法、决策理论、癌症临床试验、癌症筛查、生存分析、统计遗传学、基因组学、生物信息学和统计计算方面的教师专业知识，学员将获得现代癌症研究所需的广泛的生物统计学背景。暑期实习和实验室轮换为学生的培训提供了实践经验。 相关性：将莱斯大学和UTMDACC现有的教育资源与实践经验相结合，将使学员在完成培训后能够与生物医学研究人员一起为癌症研究做出基础性贡献。这种密切的合作将导致更有效的研究设计和数据分析，使治疗理论更快地转化为临床应用。

DESCRIPTION (provided by applicant): Project Summary: This application is for continuation of a training program in biostatistics with a specific focus on cancer research. The training program supports six students each year. The practice of biostatistics is changing, especially in the area of cancer research. Discoveries over the last two decades into the molecular, biochemical, and genetic components of cell growth and development lave changed our understanding of what makes a normal cell become cancerous and then metastasize. Multidisciplinary research teams are at the heart of modern approaches to fighting cancer, and biostatisticians more and more are a part of such teams. Such teamwork requires that the statistician be conversant with molecular biologists, pathologists, and, of course, clinical oncologists if the group of co-investigators is to succeed. Effective biostatistical collaboration thus requires broad training in statistics, probability, computational methods, as well as cancer biology and medical ethics. The Department of Statistics, Rice University, and departments in the Division of Quantitative Sciences at the University of Texas M. D. Anderson Cancer Center (UTMDACC) have joined forces with their collaborators in the clinical and basic sciences to develop a unique training program that combines their respective strengths to train biostatisticians in cancer research. The goal of this Training Program in Biostatistics is to prepare a new generation of biostatisticians who will work side-by-side with biomedical investigators in modern cancer research. Our program aims to provide trainees with Rigorous training in statistics and probability; Practical experience in basic and clinical cancer research; and Training in biological aspects of cancer and medical research ethics. Students in this program follow the standard course of study expected of Ph.D. students in the Department of Statistics at Rice, with additional coursework in biostatistics, biology, and ethics, as well as special seminars and workshops at both institutions. With faculty expertise in Bayesian methods, decision theory, cancer clinical trials, cancer screening, survival analysis, statistical genetics, genomics, bioinformatics, and statistical computing, trainees will receive a broad background in biostatistics necessary for modern cancer research. Summer internships and laboratory rotations provide practical experience in the student's training. Relevance: Combining the educational resources available at Rice University and UTMDACC with practical experience will enable trainees upon completion to make fundamental contributions to cancer research working alongside biomedical investigators. Such close collaboration will lead to more efficient study designs and data analysis, allowing translation of therapeutic theories to clinical application more quickly.