Collaborative RNAi

项目SUMM/\RY(请参阅说明)： 了解癌症发生和发展的基本生物学机制是找到更好的癌症预防和治疗方法的基础。高通量RNA干扰(RNAi)筛选是一种大规模研究基因功能的最先进的方法，包括识别新的癌症相关基因和途径。协作性RNAi核心提供了一个单一的门户，通过该门户，DF/HCC成员可以学习使用RNAi筛查和所产生的数据集来研究癌症生物学，了解满足他们的研究需要的特定筛查选项，并访问癌症中心成员以前没有始终如一地获得的RNAi设施。该核心还协调这些主要独立的RNAi单位的业务和行政职能。这一核心是在项目期间由于成员的高需求而创建的，并在本提案中作为新建立的共享资源呈现。 导演：斯蒂芬妮·莫尔博士(HMS) 类别：1.20(分子生物学)和1.37(RNAi筛选)

PROJECT SUMM/\RY (See instructions): Understanding the basic biological mechanisms that underlie the development and progression of cancer is fundamental to finding better approaches to cancer prevention and treatment. High-throughput RNA interference (RNAi) screening is a state-of-the-art method for large-scale investigation of gene function, including identification of new cancer-related genes and pathways. The Collaborative RNAi Core offers a single portal through which DF/HCC members are educated about the use of RNAi screening and resulting datasets to study cancer biology, learn about specific screening options to meet their research needs and access RNAi facilities that had not been consistently available to Cancer Center members. The Core also coordinates the operations and administrative functions of these primarily independent RNAi units. This Core was created during the project period due to high member demand and is presented as a new Established Shared Resource in this proposal. Director: Stephanie Mohr, PhD(HMS) Category: 1.20 (Molecular Biology) and 1.37 (RNAi Screening)