Nutrition and Superfund Chemical Toxicity

肯塔基州大学是唯一的土地赠款大学，因为所有学院，包括医学和农业，都位于同一个校园。这一系列计划使UK-SBRP能够在不同学科之间开展独特的富有成效的合作。这样的环境将允许研究SBRP研究的总体主题，重点是超级基金化学品的毒理学以及如何通过内在和外在因素（即遗传和营养）调节暴露的健康影响。鉴于超级基金化学品的丰富性和在生态系统中的广泛分布，单靠补救措施不太可能足以解决其健康风险。因此，营养干预成为解决与环境污染物有关的健康问题的一种明智的方式。在竞争性的更新中，研究人员通过提出五个综合项目，认识到这种通过营养进行传感/修复和生物医学干预的双重需求。调查人员将集中研究氯化有机物（例如，多氯联苯），包括在肯塔基州发现的那些。该小组的初步研究结果表明，营养和饮食习惯可显著影响上述超级基金化学品的毒性机制。因此，我们SBRP的一个主要目标是探索营养可以改变超级基金化学毒性的范例。所有的生物医学项目将集中在与血管功能障碍相关的慢性疾病，如心血管疾病，癌症转移和肥胖相关的腹主动脉瘤，并将利用类似的饮食脂肪方案来研究营养/有毒物质的相互作用。将与非生物医学项目进行重大的交叉讨论，这些项目将探索与检测多氯联苯和其他氯化有机物有关的补救（解毒）和生物传感器的新技术。跨学科研究的结果将用于信息/教育，技术转让，培训，政策和翻译目的，作为研究翻译，社区推广和培训核心目标的一部分。营养可能是制定与许多环境毒性损伤相关的疾病的初级预防策略的最明智的手段。因此，研究人员提出的研究可能会在国家一级为高危人群提供新的饮食建议，从而改善居住在超级基金地点附近的人们的健康。

The University of Kentucky is unique among land grant universities in that all colleges, including Medicine and Agriculture, are located on the same campus. This constellation of programs has enabled the UK-SBRP to develop uniquely productive collaborations across diverse disciplines. Such an environment will allow to study the overall theme of the SBRP research, which focuses on the toxicology of Superfund chemicals and how health effects of exposure can be modulated by both intrinsic and extrinsic factors, namely genetics and nutrition, respectively. Given the abundance of Superfund chemicals and widespread distribution in the ecosystem, it is unlikely that remediation alone will be sufficient to address their health risks. Nutritional intervention thus becomes a sensible way to address health problems associated with environmental pollutants. In the competing renewal, the investigators recognize this dual need for sensing/remediation and biomedical intervention through nutrition by proposing five integrated projects. The investigators will concentrate on chlorinated organics (e.g., polychlorinated biphenyls) prevalent in most Superfund sites, including those found in Kentucky. Preliminary findings by this group suggest that nutrition and dietary habits can markedly influence mechanisms of toxicity of the above-mentioned Superfund chemicals. Thus, a major objective of our SBRP is to explore the paradigm that nutrition can modify Superfund chemical toxicity. All biomedical projects will focus on chronic diseases associated with vascular dysfunction, such as cardiovascular disease, cancer metastasis, and obesity-related abdominal aortic aneurysms, and will utilize a similar dietary fat regimen to study nutrient/toxicant interactions. There will be significant cross-talk with non-biomedical projects, which will explore novel techniques for both remediation (detoxification) and biosensors associated with detection of PCBs and other chlorinated organics. Results from interdisciplinary research will be utilized for information/education, technology transfer, training, policy and translational purposes as part of the objectives of the Research Translation, Community Outreach, and Training Cores. Nutrition may be the most sensible means to develop primary prevention strategies of diseases associated with many environmental toxic insults. Thus, research proposed by the investigators may lead to novel dietary recommendations at the national level for populations at risk, thus improving the health of people residing near Superfund sites.