COBRE Center for Evolutionary and Theoretical Immunology

描述(由申请者提供)：在NIH IDEA Cobre项目的资助下，进化和理论免疫学中心(CETI)于2003年成立。CETI的主题重点领域是进化-比较和理论免疫学，这源于在新墨西哥大学生物学和计算机科学系和洛斯阿拉莫斯国家实验室拥有共同兴趣的教职员工的独特汇聚。在Cobre的支持下，CETI已经聘请了六名终身教职员工，并利用生物学大楼中16,000平方英尺的新建筑空间来容纳我们的项目。CETI的调查人员现在已经发表了576篇科学论文，并成功竞争了3990万美元的研究资金。此外，CETI的主要目标之一是改善和维护科学基础设施，使我们的科学家在获得外部支持方面更具竞争力。为此，我们与我们的支持性行政核心一起，建立了三个广泛使用的科学核心：分子生物学核心和受控环境核心，这两个核心都是在我们的资助第一阶段建立的，还有一个细胞生物学核心是在第二阶段建立的。我们第三阶段的目标是通过购买更多的设备和聘请技术支持来进一步改进和扩大我们的三个科学核心。我们还建议通过继续我们广受欢迎的试点项目和豁免计划来进一步扩大我们的用户基础。为了配合这些项目，我们为所有参与者提供广泛的指导，以增加他们获得自己的外部资金的可能性，并增加他们在学术界取得长期成功的前景。第三阶段的另一个重要目标是将我们的每个核心转换到成本中性状态，从而减少我们对Cobre支持的依赖。因此，我们将逐步实施有助于我们在第三阶段结束时实现这一目标的商业模式。最后，为了帮助从Cobre支持过渡，我们已从UNM行政部门获得88.75万美元的支持承诺，将在第三阶段(CETI存在的第16年至第20年)后应用，以帮助我们维持CETI的独立性。通过建立一支能够竞争个人和多项PI拨款的研究人员队伍，我们相信CETI将实现IDEA计划的目标，促进新墨西哥州研究竞争力的提高和科学基础设施的发展。

DESCRIPTION (provided by applicant): With funding from the NIH IDeA COBRE program, the Center for Evolutionary and Theoretical Immunology (CETI) was launched in 2003. CETI's thematic focus area, in evolutionary-comparative and theoretical immunology, stems from a unique confluence of faculty with shared interests in the Departments of Biology and Computer Science at UNM and at the Los Alamos National Laboratories. With COBRE support, CETI has hired six tenure-track faculty and has leveraged 16,000 SF of new building space in the Biology building to accommodate our program. CETI investigators have now published 576 scientific papers and successfully competed for $39.9 million in research funds. In addition, one of CETI's key goals is to improve and maintain scientific infrastructure to enable our scientists to be even more competitive in securing extramural support. Towards that end, along with our supportive Administrative Core, we have established three extensively-used scientific Cores: a Molecular Biology Core and a Controlled Environments Core, both established in Phase I of our funding, and a Cell Biology Core established in Phase II. Our goals for Phase III are to further improve and expand our three scientific Cores through purchase of additional equipment and hiring of technical support. We also propose to further increase our user base by continuing our popular Pilot Project and Waiver programs. To go along with these programs, we offer all participants extensive mentoring to increase their likelihood of securing their own extramural funding and increasing their prospects for long term success in academia. Another important goal of Phase III is to transition each of our Cores to a cost neutral status, thus reducing our dependence on COBRE support. Consequently, we will phase in business models that will help us achieve this goal by the end of Phase III. Finally, to aid in transition from COBRE support, we have secured a pledge of $887,500 in support from UNM's administration to be applied post-Phase III (in years 16 through 20 of CETI's existence) to help us sustain CETI's independence. By building a critical mass of investigators able to compete for both individual and multi-PI grants, we are confident that CETI will achieve the goals of the IDeA program in promoting increased research competitiveness and scientific infrastructure development in the state of New Mexico.