Chemistry-Biology Interface Training Grant

描述（由申请人提供）：这是化学生物学接口（CBI）培训资助T32 GM 08804的第一次更新。我们设计了一个跨学科的计划，用于培养学生（和教师）在生物，医药和传统化学的接口，称为生物化学计划（BCP）。该计划于2000年秋季开始，为对生物化学感兴趣的学生提供重点，跨学科的教育。该计划完全融入三个参与部门，学生可以获得化学，生物化学和分子生物物理学或药理学和毒理学（药物化学部）的学位，同时遵循生物化学培训计划。学生在所有三个部门进行课程，在至少两个部门进行研究轮换，并参加每周的BCP研究论坛，学生和教师在那里展示研究成果。重要的是，学生可以与任何人在该计划，无论部门的隶属关系，允许真正的多学科研究工作。培训教师包括来自四个部门的34个高度活跃的研究小组。学生在BCP保持活跃，直到毕业。目前有36名学生参加培训方案，其中21名符合培训补助金条件;预计秋季将有另外6-10名学生参加。自2000年成立以来，已有8名学生完成了博士学位课程。℃下培训补助金插槽通常是在该计划的第2年和第3年，使培训补助金获得者在组装多学科研究项目时具有很大的灵活性。奖学金在学生第二学期结束时颁发，在他们选择论文导师之前，以协助组建一个基础广泛的团队。对于6-10年，我们要求每年8个培训补助金名额，允许每年颁发四个2年奖学金，并且在任何给定时间都可以资助我们的培训补助金合格学生的约1/3。化学-生物学接口的培训与公共卫生的进步高度相关。许多最重要的发现都发生在一个或多个学科的交叉点上，一个领域的知识被用来解决另一个领域的问题。通过混合化学，药物化学和生物化学，我们的学员准备在药物发现，疾病检测，疾病预防和发现疾病的根本原因方面取得下一个突破。

DESCRIPTION (provided by applicant): This is the first renewal of Chemistry-Biology Interface (CBI) training grant T32 GM08804. We have designed an interdisciplinary program for training students (and faculty) at the interface of biological, medicinal, and traditional chemistry, called the Biological Chemistry Program (BCP). This program, which began in the fall of 2000, provides a focused, cross-disciplinary education for students interested in biological chemistry. The program is fully integrated into the three participating departments and students may obtain a degree in Chemistry, Biochemistry and Molecular Biophysics, or Pharmacology and Toxicology (Medicinal Chemistry Division) while following the Biological Chemistry Training Program. Students undertake coursework in all three departments, perform research rotations in at least two departments and participate in the weekly BCP research forum, where students and faculty present research results. Importantly, students may work with anyone in the program, regardless of departmental affiliation, allowing for true multi- disciplinary research efforts. The training faculty includes 34 highly-active research groups from four departments. Students remain active in the BCP until graduation. There are 36 students currently following the training program, 21 of which are training grant eligible; an additional 6-10 students are expected to join in the fall. Since inception in 2000, 8 students have completed the program with a PH.D. degree. Training grant slots are generally made for years 2 and 3 in the program, allowing training grant recipients great flexibility in assembling a multi-disciplinary research project. Fellowships are awarded near the end of the student's second semester, before they choose a thesis advisor, to assist in assembling a broad-based team. For years 6-10, we request 8 training grant slots per year, allowing for four 2-year fellowships to be awarded per year, and ~1/3 of our training-grant-eligible students to be funded at any given time. Training at the Chemistry-Biology Interface is highly relevant for advances in public health. Many of the most important discoveries occur at the intersection of one or more disciplines, where the knowledge of one field is brought to bear on the problems of another. By blending Chemistry, Medicinal Chemistry and Biochemistry, our trainees are poised to make the next breakthroughs in drug discovery, disease detection, disease prevention, and the discovery of the underlying causes of disease.