Immunohematology/Transfusion Medicine Research Training

描述（由申请人提供）： 该提案是为了更新我们于2001年启动的免疫血液学和输血医学博士后研究培训补助金。该计划提供了一个高度组织化的2-3年计划，重点是专门的教学法，研讨会，最重要的是，与代表八个不同的主要部门的24位成熟，高度互动，资金充足的跨学科导师之一的密集研究经验。其目标是产生富有成效的MD和MD/PhD医生-科学家以及博士科学家和临床科学家，他们将在这个代表性不足的领域开展终身研究事业，从事基础和转化研究。由个性化的“职业与研究委员会”精心职业发展是该计划的一个标志。除了核心博士后课程外，还提供三个学位授予“轨道”：一个调查医学博士学位，提供给希望获得更广泛的研究背景模仿MD/博士学位的MD学员;耶鲁CTSA赞助下的健康科学硕士学位，用于临床/转化研究目标;和生物医学工程硕士学位的学员与过去的基本生物医学的重点谁希望增加一个工程方面，他们的知识基础。从一个专注于那些背景是实验室医学和病理学的候选人库中抽取（一个总是包括至少10倍以上的优秀候选人的库），结果是相当积极的。在T32计划的毕业生中，25%的人成功完成了学位授予，50%的人获得了终身教职的学术调查职位，其余的人在早期的职业发展阶段保留在研究中;所有人都获得了一些后续资金，25%直接进入K 08奖项。T32计划目前每年支持四个博士后职位，根据结果和候选人库，我们要求增加到六个职位。“核心”T32是“杠杆”，因为整个实验室医学系免疫血液学-输血医学培训计划大于T32 -它包括其他资助机制的个人。当他们被包括在内时，69%的毕业生拥有调查终身职位，38%的毕业生获得了PI级R 01资助。我们相信，该计划填补了一个重要的研究培训需要在耶鲁大学和国家。

DESCRIPTION (provided by applicant): This proposal is for renewal of our postdoctoral research training grant in Immunohematology and Transfusion Medicine that was initiated in 2001. The program provides a highly organized 2-3 year program of focused dedicated didactics, seminars, and, most importantly, an intense research experience with one of 24 well-established, highly interactive, and well-funded cross-disciplinary mentors representing eight different primary departments. The goal is to generate productive MD and MD/PhD physician- scientists as well as PhD scientists and clinician-scientists, who will be launched on a lifelong investigative career pursuing basic and translational research in this underrepresented field. Careful career development by an individualized "Career & Research Committee" is a hallmark of the program. Three degree-granting "tracks" are also available, in addition to the core post-doctoral program: an Investigative Medicine PhD available to MD-only trainees who wish to obtain a more expansive research background mimicking that of an MD/PhD; a Masters of Health Sciences under the aegis of the Yale CTSA for those with a clinical/translational research goal; and a Masters of Biomedical Engineering for trainees with a past basic biomedicine emphasis who wish to add an engineering dimension to their knowledge base. Drawn from a candidate pool focused on those whose background is Laboratory Medicine & Pathology (a pool which has always included at least 10 fold more excellent candidates than are accepted into the program), outcomes have been quite positive. Of the graduates of the T32 program, 25% have successfully completed a degree-granting track, 50% have secured tenure track academic investigative positions, with the remainder retained in research at earlier career development stages; all have obtained some subsequent funding with 25% moving directly to K08 awards. The T32 program currently supports four post-doctoral positions per year and, based on results and candidate pool, we are requesting an increase to six positions. The "core" T32 is "leveraged", since the entire Laboratory Medicine Departmental Immunohematology-Transfusion Medicine training program is greater than the T32 - it includes individuals on other funding mechanisms. When they are included, 69% of graduates have investigative tenure track positions and 38% have attained PI-level R01 funding. We believe that this program fills an important research training need both at Yale and nationally.