Shanghai Men's Health Study

描述(由申请人提供)：上海男性健康研究(SMHS)由NCI自2001年起资助(R0I CA082729)，是一项基于人群的队列研究，对象为61,491名男性，在2002至2006年间招募，并通过多次面对面跟踪调查和记录联系进行跟踪。多年来，SMHS收集的数据和生物样本已被用于评估许多重要的病因学假说，并支持多项研究，包括超过25个联盟项目。为了维持和扩大其资源和成功，我们正在申请基础设施资金，具体目标如下：1)继续跟踪这一队列的癌症发病率和特定原因的死亡率，并通过进行面对面访谈来扩大队列的资源，以更新暴露和选定疾病结果的信息；2)维护SMHS的数据库和生物库，并实施质量控制协议，以最大限度地发挥其资源用于科学研究的价值；3)收集6,000名研究参与者的血液和尿液样本，以增强我们研究中间疾病生物标志物的能力，这是基线评估和后续跟踪评估的结果；4)通过搜索覆盖研究人群的电子健康信息系统的数据库，为队列成员收集与诊断和治疗常见慢性病有关的信息；5)为被诊断为肺癌、胃癌、结肠癌/直肠癌、肝癌和前列腺癌的参与者收集肿瘤组织样本和关于癌症治疗、复发和生存的详细信息，以及为胃癌、结肠癌/直肠癌和前列腺癌幸存者收集诊断后生活方式因素和生活质量信息；6)建立一个网站，促进和促进更广泛的癌症研究人员之间的合作，传播研究成果，吸引和培养新的研究人员。SMHS凭借其庞大的样本量、丰富的资源以及独特的暴露模式和疾病谱，提供了解决许多重要假设的特殊机会，这些假设在任何其他现有的队列研究中都无法得到充分研究。继续对该队列采取后续行动并扩大其资源将进一步提高SMHS在癌症和其他慢性疾病的长期流行病学研究方面的价值。

DESCRIPTION (provided by applicant): The Shanghai Men's Health Study (SMHS), funded by NCI since 2001 (R0I CA082729), is a population based cohort study of 61,491 men who were recruited between 2002 and 2006 and have been followed through multiple in-person follow-up surveys and record linkages. Over the years, data and biological samples collected in the SMHS have been used to evaluate many important etiologic hypotheses and support multiple studies, including over 25 consortium projects. To both sustain and expand its resources and success, we are applying for infrastructure funding with the following specific aims: 1) Continue the follow-up of this cohort for cancer incidence and cause-specific mortality and expand the cohort's resources by conducting in-person interviews to update information on exposures and selected disease outcomes; 2) Maintain the data bank and biorepository of the SMHS and implement quality control protocols to maximize the value of its resources for scientific research; 3) Collect blood and urine samples from 6,000 study participants to enhance our ability to study intermediate disease biomarkers as a consequence of exposures assessed at the baseline and subsequent follow-ups; 4) Collect information related to the diagnosis and treatment of common chronic diseases for cohort members by searching the database of an electronic Health Information System covering the study population; 5) Collect tumor tissue samples and detailed information on cancer treatment, recurrence, and survivorship for participants diagnosed with cancers of the lung, stomach, colon/rectum, liver, and prostate, the five most common cancers in the cohort, as well as collect post-diagnosis lifestyle factor and quality of life information for survivors of stomach, colon/rectum, and prostate cancer; 6).To build a website to promote and facilitate collaborations among the broader community of cancer researchers, to disseminate research findings, and to attract and cultivate new investigators. The SMHS, with its large sample size, wealth of resources, and unique exposure patterns and disease spectrum, provides exceptional opportunities to address many significant hypotheses that cannot be adequately investigated in any other existing cohort study. Continuing follow-up of the cohort and expansion of its resources would further increase the value of the SMHS for a long-term epidemiologic study of cancer and other chronic diseases.