DTI, MRSI, and Volumetry of Cerebellar Injury in Preterm Neonates

项目概要： 在美国，13%到16%的新生儿是早产儿，其中近2%是早产儿。 重量小于1500克（小于四分之三磅）。在后一组中， 在近90%的幸存者中观察到：脑瘫在5-10%中被发现， 认知、行为或注意力在约50%中被发现。2005年，生命第一年的医疗费用 平均为41，610美元，而足月婴儿为2830美元，每年的医院费用为7.4美元 亿磁共振成像越来越多地用于观察这些婴儿的大脑， 以了解为什么这么多人有这些发育异常。大多数研究都集中 在大脑半球的白色物质损伤后， 小脑发育异常，小脑是大脑的一个更靠后的部分。小脑有 传统上与运动张力和协调有关，最近已被牵连 在认知功能上。因此，早产的不良后果的一个组成部分可能与以下方面有关： 小脑发育异常这项研究建议使用最先进的磁共振技术 技术，以评估在发育过程中小脑的代谢和微观结构， 早产新生儿，并将其发展与潜在的可治疗的条件相关联， 其他器官系统的婴儿和两个共同的条件大脑在早产儿 新生儿：脑室出血和脑白色物质损伤。据推测 脑室系统和小脑周围蛛网膜下腔的出血 小脑从覆盖它的组织接收重要信号，而大脑损伤 白色物质可能会干扰发送到小脑的信号，从而导致小脑损伤。 早熟的大脑查明原因可能有助于避免这些因素， 更积极地治疗，最终减少小脑损伤并改善临床结果。 项目/履约现场（如果需要额外空间，请使用项目/履约现场格式页） 项目/绩效现场主要位置 组织名称：加州大学旧金山分校弗朗西斯科 电话：608379298 Registrant Street 1：hebeishengshanshi 城市：旧金山弗朗西斯科州：CA 邮编：94143-0628 San弗朗西斯科 县： 项目/绩效现场国会选区： 其他项目/绩效现场位置 组织名称： DUNS： 第一街：第二街： 城市：州： 省份：国家：邮政编码：县： 项目/绩效现场国会选区：

PROJECT SUMMARY: Between 13 and 16% of children born in the united States are born prematurely, with nearly 2% of these weighing less than 1500 g (less than three-quarters of a pound). In this latter group, neurological deficits are observed in nearly 90% of those who survive: cerebral palsy is found in 5-10% and deficits in cognition, behavior, or attention is found in about 50%. In 2005, medical costs during the first year of life averaged $41,610, compared to $2830 for a full term baby, for total annual hospital charges of $7.4 billion. Magnetic resonance imaging is being used increasingly to look at the brains of these babies in order to understand why so many have these developmental abnormalities. Most studies have focused upon injury to the white matter of the cerebral hemispheres, but recent studies have discovered frequent abnormalities of development of the cerebellum, a more posterior part of the brain. The cerebellum has traditionally been associated with motor tone and coordination, and more recently has been implicated in cognitive function. As a result, a component of the adverse outcome from prematurity may relate to abnormal cerebellar development. This study proposes to use state-of-the-art magnetic resonance techniques to assess the metabolism and microstructure of the cerebellum during development in prematurely born neonates and to correlate that development with potentially treatable conditions in other organ systems of the baby and with two common conditions of the brain in prematurely born neonates: hemorrhage into the cerebral ventricles, and injury of the cerebral white matter. It is postulated that hemorrhage into the ventricular system and subarachnoid spaces around the cerebellum prevents the cerebellum from receiving important signals from the tissues that cover it, while injury to the cerebral white matter might interfere with signals sent to the cerebellum, thus contributing to cerebellar injury of the premature brain. Identification of the causative factors might allow those factors to be avoided or treated more aggressively, ultimately resulting in less cerebellar damage and improved clinical outcome. PROJECT/PERFORMANCE SITE (S) (if additional space is needed, use Project/Performance Site Format Page) Project/Performance Site Primary Location Organizational Name: University of California at San Francisco DUNS: 608379298 Street 1: 505 Parnassus Avenue Street 2: City: San Francisco State: CA Province: Country: USA Zip/Postal Code: 94143-0628 San Francisco County: Project/Performance Site Congressional Districts: Additional Project/Performance Site Location Organizational Name: DUNS: Street 1: Street 2: City: State: Province: Country: Zip/Postal Code: County: Project/Performance Site Congressional Districts: