Gamma counter and continuous blood sampler for quantitative PET imaging

描述（由申请人提供）：在马萨诸塞州总医院使用PET、PET/MR和生物分布的临床前、转化和临床研究项目得到了NIH和其他联邦机构的积极支持。这些计划正在解决肿瘤学，精神病学，神经病学，心脏病学，内分泌学，基础神经科学和肺部疾病的关键问题。准确测量血液和组织样本中的放射性对于定量PET成像和生物分布研究至关重要。血液测量对于确定放射性标记化合物的药代动力学是必要的，其提供了对该药剂在体内的作用的了解，并且可以用于量化在体内其他地方获得的成像数据。同样地，组织测量告知研究者放射性标记化合物的最终命运，其产生关于靶向功效的关键信息（例如，药物到达肿瘤的能力），并可用于确认临床前研究中成像数据的准确性。在这份申请中，我们要求资助购买一个国家的 用于血液和组织测量的现有技术系统，其包括用于测量离散样本的自动多样本计数器和用于连续血液采样的MR兼容泵和检测系统。该仪器将取代我们过时和不可靠的手动单样本计数器，并提供我们的第一个连续血液测量设备，这将促进正在进行的项目，使新的研究方向在未来，并提供现代硬件的这部分动手经验，研究员在我们的T32计划“研究生培训计划在医学成像”暴露。

DESCRIPTION (provided by applicant): Preclinical, translational, and clinical research projects using PET, PET/MR, and biodistribution at Massachusetts General Hospital are actively supported by the NIH and other federal agencies. These programs are addressing critical issues in oncology, psychiatry, neurology, cardiology, endocrinology, basic neuroscience, and pulmonary disease. Accurate measurement of radioactivity in blood and tissue samples is essential for quantitative PET imaging and biodistribution studies. Blood measurements are necessary for determining the pharmacokinetics of a radiolabeled compound, which provides insights into the action of that agent in the body and can be used to quantify imaging data acquired elsewhere in the body. Likewise, tissue measurements inform the investigator of the ultimate fate of a radiolabeled compound, which yields key information on targeting efficacy (e.g., ability of a drug to reach a tumor) and can be used to confirm the accuracy of imaging data in preclinical studies. In this application, we request funding for the purchase of a state-of the-art system for blood and tissue measurement that includes an automatic multi-sample counter for measurement of discrete samples and an MR-compatible pump and detection system for continuous blood sampling. This instrumentation will replace our antiquated and unreliable manual single-sample counter and provide our first continuous blood measurement device, which will facilitate ongoing projects, enable new research directions in the future, and offer modern hardware for this portion of the hands-on experience that fellows in our T32 program "Postgraduate Training Program in Medical Imaging" are exposed to.