Translational and Clinical Research

翻译和临床研究计划的目标是从基础科学中带来新的见解 西特曼癌症中心的创新临床试验将对 改善对患者的肿瘤学护理。我们特别强调的是利用来自信令的信息 (例如，FGFR2在子宫内膜癌中，NF1在胶质母细胞瘤中，RET在甲状腺癌中)。基因组学 (肺癌、胶质母细胞瘤、前列腺癌和直肠癌)和肿瘤学成像(前列腺癌、肺癌 以及食道癌和甲状腺癌)，用于临床研究的设计、分析和解释 试验和研究。该计划还促进了与预防和控制计划的合作 并从前列腺癌筛查等领域获得了赠款、出版物和临床项目 以及共病研究。转化和临床研究计划为以下项目提供支持网络 扩展的发展治疗计划侧重于机构阶段0、1和II研究。这个 该计划还支持以疾病为基础的工作组开发、审查、确定优先顺序并进行临床试验 研究，特别强调肺癌、子宫内膜癌、前列腺癌和G1癌的工作组，以及 神经肿瘤学。此外，翻译和临床研究计划将提供以下培训 所有级别的调查人员的经验和培养教育机会，包括研讨会，课程， 务虚会、日记俱乐部、研讨会和进行中的会议。 翻译和临床研究计划有来自15个科室和2个学院的74名成员。这个 该计划得到24,979,138美元的资助，其中11,438,989美元来自NCI资助，10,835,323美元来自 其他同行评审的资金。在上一次的资助期间，转化和临床研究的成员 计划发表稿件1157篇，其中24.90%为计划间稿件，23.43%为结果稿件 从方案内部协作中获益。

The goal ofthe Translational & Clinical Research Program is to bring new insights from Basic Sciences Programs ofthe Siteman Cancer Center into innovative clinical trials that will have an important impact on improving oncologic care for patients. Our particular emphasis is on utilizing information from Signaling Pathways, (eg FGFR2 in endometrial cancer, NF1 in glioblastoma, and RET in thyroid cancer). Genomics (lung cancer, glioblastoma, prostate cancer and rectal cancer), and Oncologic Imaging (prostate cancer, lung and esophageal cancers, and thyroid cancer) for the design, analysis, and interpretation of clinical research trials and studies. Collaborations with the Prevention and Control Program are also fostered by this program and have resulted in grants, publications and clinical projects from areas including prostate cancer screening and co-morbidity studies. The Translational & Clinical Research Program provides the supporting network for an expanding Developmental Therapeutics Program focused on institutional phase 0,1, and II studies. The program also supports disease-based working groups to develop, review, prioritize, and conduct clinical trials research, with special emphasis on working groups in lung, endometrial, prostate, and Gl cancer, and Neuro-Oncology. Furthermore, the Translational & Clinical Research Program will provide training of investigators at all levels of experience and foster educational opportunities including seminars, courses, retreats, journal clubs, workshops, and work-in-progress meetings. The Translational & Clinical Research Program has 74 members from 15 Departments and 2 Schools. The Program is supported by $24,979,138 in funding of which $11,438,989 in NCI funding and $10,835,323 in other peer reviewed funding. In the last grant period, members of the Translational & Clinical Research Program published 1,157 manuscripts, of which 24.90% represent inter-programmatic and 23.43% resulted from intra-programmatic collaborations.