Center for Translational Neuroscience

描述(由申请人提供)：我们的总体目标是建立一个永久性的转化神经科学中心(CTN)，致力于：a)为维护和扩大在第一阶段和第二阶段发展的自给自足的研究核心提供支持，这些研究核心对于基础、临床、转化和社区研究的继续进行至关重要，以及b)通过为先导研究项目以及指导和培训部分提供支持，维持一个协作的、多学科的研究环境。为实现这一目标，我们设计了以下具体目标：目标1：通过支持、升级和精简三个核心设施，加强对CTN至关重要的基础设施。目标2：通过由公认的、敬业的高级导师指导有前途的早期职业临床医生和基础科学家，加强和扩大与翻译任务相关的研究。目标3：扩大我们针对CTN研究人员的成功职业发展计划，并为成熟的和年轻的研究人员建立一个新的领导力计划，这些研究人员将被要求达到特定的业绩里程碑。目标4：支持尖端科学的转化性先导研究计划，促进全州范围内和机构内部的更多合作，并创造机会开发和保持有竞争力的研究计划。目标5：系统地收集、分析和使用CTN信息来回答有关项目、核心和政策的问题，特别是关于其效率和效果的问题。一个经验丰富的核心咨询委员会(CAC)将监督所有核心设施的运营和使用。外部咨询委员会(EAC)将监督试点研究的科学竞争力，并审查职业发展计划和合作研究的进展情况。内部咨询委员会将监督早期职业调查员的整合以及与征聘、空间、晋升和终身教职有关的问题。这些目标将对我们这样一个小机构产生更大的影响，并促进一个成功和多产的CTN的巩固，为国家计划树立榜样。我们可能的成功是通过产生超过3000万美元的新赠款支持，并在第一和第二阶段发表超过450篇文章和章节来证明的。

DESCRIPTION (provided by applicant): Our overall goal is the establishment of a permanent Center for Translational Neuroscience (CTN) dedicated to, a) providing support for maintaining and expanding self-sufficient research cores developed during Phases I and II that are essential for the continuing conduct of basic, clinical, translational, and community based research, and b) sustaining a collaborative, multidisciplinary research environment by providing support for pilot study projects, as well as mentoring and training components. To attain this goal, we designed the following specific aims: Aim 1: To enhance the infrastructure critical to the CTN by supporting, upgrading, and streamlining three Core Facilities. Aim 2: To strengthen and augment translational mission relevant research through mentoring promising early career clinicians and basic scientists by established, dedicated senior Mentors. Aim 3: To expand our successful Career Development Program for CTN investigators and institute a new Leadership Program for established and young researchers, who will be required to meet specific Performance Milestones. Aim 4: To support a translational pilot study research program of cutting edge science, promote state wide and additional collaborations within the institution, and create opportunities to develop and maintain competitive research programs. Aim 5: To systematically collect, analyze, and use CTN information to answer questions about projects, cores, and policies, especially about their efficiency and effectiveness. An experienced Core Advisory Committee (CAC) will oversee operation and utilization of all the Core Facilities. The External Advisory Committee (EAC) will oversee scientific competitiveness of pilot studies and review progress of the Career Development Program and collaborative research. The Internal Advisory Committee (lAC) will oversee integration of early career investigators and issues related to recruitment, space, and promotion and tenure. These aims will have a greater impact at a small institution such as ours and facilitate the solidification of a successful and productiv CTN that will set an example for national programs. Our likely success is certified by generating over $30 million in new grant support and publishing over 450 articles and chapters in Phses I and II.